ArticleProceedings of the National Academy of Sciences of the United States of America2019
Self-organizing motors divide active liquid droplets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Elucidating the Reciprocal Interplay between Supramolecular Polymer Cytoskeletons and Fuel-Dependent Synthetic Cells.Journal of the American Chemical Society · 2026Article
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function.Mechanobiology in medicine · 2026Review
- Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets.Nature communications · 2026Article
- Theory of active self-organization of dense nematic structures in the actin cytoskeleton.eLife · 2025Article
- Dynamic shape remodeling of vesicles by internal active filaments.Biophysical journal · 2025Article
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Growth-induced collective bending and kinetic trapping of cytoskeletal filaments.Cytoskeleton (Hoboken, N.J.) · 2024Article
- Anomalous dynamics of a passive droplet in active turbulence.Nature communications · 2024Article
- Kinetic trapping organizes actin filaments within liquid-like protein droplets.Nature communications · 2024Article
- Growth-induced collective bending and kinetic trapping of cytoskeletal filaments.bioRxiv : the preprint server for biology · 2024Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Self-emergent vortex flow of microtubule and kinesin in cell-sized droplets under water/water phase separation.Communications chemistry · 2023Article
- Collective transport and reconfigurable assembly of nematic colloids by light-driven cooperative molecular reorientations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Growth, replication and division enable evolution of coacervate protocells.Chemical communications (Cambridge, England) · 2022Review
- Thermodynamic Control of Activity Patterns in Cytoskeletal Networks.Physical review letters · 2022Article
- Nucleation causes an actin network to fragment into multiple high-density domains.Biophysical journal · 2022Article
- Leveraging ultra-low interfacial tension and liquid-liquid phase separation in embedded 3D bioprinting.Biophysics reviews · 2022Review
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Authors and funding
5 authors.
Funding
Abstract
The cytoskeleton is a collection of protein assemblies that dynamically impose spatial structure in cells and coordinate processes such as cell division and mechanical regulation. Biopolymer filaments, cross-linking proteins, and enzymatically active motor proteins collectively self-organize into various precise cytoskeletal assemblies critical for specific biological functions. An outstanding question is how the precise spatial organization arises from the component macromolecules. We develop a system to investigate simple physical mechanisms of self-organization in biological assemblies. Using a minimal set of purified proteins, we create droplets of cross-linked biopolymer filaments. Through the addition of enzymatically active motor proteins, we construct composite assemblies, evocative of cellular structures such as spindles, where the inherent anisotropy drives motor self-organization, droplet deformation, and division into two droplets. These results suggest that simple physical principles underlie self-organization in complex biological assemblies and inform bioinspired materials design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.