ArticleProceedings of the National Academy of Sciences of the United States of America2019
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 6 of them syntheses that pooled it.
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232citing papers in PubMed, 6 pooled it
62.3field-weighted citation impact, top 1% of its field
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Who cites it
232 citing papers in PubMed, 6 syntheses or guidelines pooled it, 356 citations in OpenAlex.
- The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases.Journal of advanced research · 2025Pooled it
- Decoding depression: a comprehensive multi-cohort exploration of blood DNA methylation using machine learning and deep learning approaches.Translational psychiatry · 2024Pooled it
- A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes.Genome medicine · 2023Pooled it
- Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2023Pooled it
- Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.Nature communications · 2022Pooled it
- Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.Genome biology · 2021Pooled it
- Childhood maltreatment and inflammatory biomarkers associated with depressive severity in adolescents with major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Circulating Cell-Free DNA Methylation Profiling Enables Detection, Distinction, and Estrogen Receptor Status Classification of Advanced Breast Cancer.Cancer research · 2026Article
- A single-cell atlas of peripheral immunity suggests immune subset attrition during tuberculosis dissemination.The Journal of international medical research · 2026Article
- Article
- Dual proximity-based interactome mapping of FKBP51 and FKBP52 uncovers shared metabolic networks.Biochemical and biophysical research communications · 2026Article
- Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Article
- Corticosterone-linked microglial activity underpins sexually dimorphic neuroplasticity after ketamine anesthesia.Science advances · 2026Article
- Histone acetylation promotes FKBP5 to increase reparative dentin formation in pulp repair.Stem cells translational medicine · 2026Article
- FKBP10 may affect the malignant phenotype of oral squamous cell carcinoma cells through the ECM/WNT signaling pathway.Scientific reports · 2026Article
- Mechanistic insights into PFAS-induced effects on B lymphocyte activation and antibody secretion.Archives of toxicology · 2026Article
- Region-specific regulation of glucocorticoid and mineralocorticoid receptor signaling in a mouse model of oral contraceptive exposure.bioRxiv : the preprint server for biology · 2026Article
- FKBP51 inhibition by SAFit2 modulates tau pathology and cognitive deficits in PS19 mice.Alzheimer's research & therapy · 2026Article
- The aging paradox of Cushing's syndrome: Stress without clear senescence?Journal of neuroendocrinology · 2026Review
- scRNA-Seq reveals anti-lymphoma immune responses in mogamulizumab-associated skin eruptions.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
172 more citing papers are in PubMed but not listed here.
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Authors and funding
33 authors at 12 institutions in 4 countries.
Anthony S ZannasDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany; aszannas@gmail.com binder@psych.mpg.de.
Meiwen JiaDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Kathrin HafnerDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Jens BaumertInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Tobias WiechmannDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Julius C PapeDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Janine ArlothDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Maik KödelDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Silvia MartinelliDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Maria RoitmanDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Simone RöhDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.ORCID 0000-0002-7450-0871
Andreas HaehleDepartment of Chemistry, Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, 64289 Darmstadt, Germany.
Rebecca T EmenyGeisel School of Medicine, Dartmouth College, Lebanon, NH 03755.
Stella IuratoDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Tania Carrillo-RoaDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, 00100 Helsinki, Finland.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, 00100 Helsinki, Finland.
Johan G ErikssonDepartment of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, 00100 Helsinki, Finland.
Amanda J DrakeUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Melanie WaldenbergerInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Simone WahlInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Sonja KunzeInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Susanne LucaeDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Bekh BradleyAtlanta Veterans Affairs Medical Center, Decatur, GA 30033.
Christian GiegerInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Felix HauschDepartment of Chemistry, Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, 64289 Darmstadt, Germany.
Alicia K SmithDepartment of Psychiatry and Behavioral Sciences, Emory University Medical School, Atlanta, GA 30322.ORCID 0000-0002-8537-5156
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University Medical School, Atlanta, GA 30322.
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Karl-Heinz LadwigInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, D-85764 Neuherberg, Germany.
Theo ReinDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Nils C GassenDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany; aszannas@gmail.com binder@psych.mpg.de.
Max Planck Institute of Psychiatry · DEHelmholtz Zentrum München · DEEmory University · USUniversity of Helsinki · FITechnische Universität Darmstadt · DEBritish Heart Foundation · GBDartmouth College · USHarvard University · USTUM Klinikum · DEUniversity Hospital Bonn · DEUniversity of Liverpool · GBUniversity of North Carolina at Chapel Hill · US
Funding
Projevt 5: Effects of the CRF1 receptor antagonist in patients w/PTSD: a plcebocoU19MH069056 · NIMH · EMORY UNIVERSITY · PI MAYBERG, HELEN S · 2003 to 2013
$15.4MNIMH NIH HHS U19 MH069056
Abstract
Aging and psychosocial stress are associated with increased inflammation and disease risk, but the underlying molecular mechanisms are unclear. Because both aging and stress are also associated with lasting epigenetic changes, a plausible hypothesis is that stress along the lifespan could confer disease risk through epigenetic effects on molecules involved in inflammatory processes. Here, by combining large-scale analyses in human cohorts with experiments in cells, we report that FKBP5, a protein implicated in stress physiology, contributes to these relations. Across independent human cohorts (total
Indexed as
AgingCardiovascular DiseasesCellular SenescenceChild, PreschoolEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansInflammationMajor Depressive DisorderMaleNF-kappa BRisk FactorsSignal TransductionStress, PsychologicalTacrolimus Binding Protein 5NF-kappa BTacrolimus Binding Protein 5Tacrolimus Binding ProteinsagingepigeneticsFKBP5inflammationpsychosocial stress
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.