Evidence map›Paper›PMID 31113875›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine.

Chih-Chia Su, Philip A Klenotic, Jani Reddy Bolla, Georgiana E Purdy, Carol V Robinson, Edward W Yu

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 147 citations in OpenAlex.

  1. Structure, assembly, and mechanism of the MmpL family of transporters.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Journal of bacteriology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Lipid Trafficking in Diverse Bacteria.Accounts of chemical research · 2025
    Review
  19. Article
  20. TheScience advances · 2024
    Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chih-Chia SuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Philip A KlenoticDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Jani Reddy BollaDepartment of Chemistry, University of Oxford, OX1 3QZ Oxford, United Kingdom.ORCID 0000-0003-4346-182X
Georgiana E PurdyDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239.
Carol V RobinsonDepartment of Chemistry, University of Oxford, OX1 3QZ Oxford, United Kingdom.ORCID 0000-0001-7829-5505
Edward W YuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; edward.w.yu@case.edu.ORCID 0000-0001-5912-1227
University School · USUniversity of Oxford · GBOregon Health & Science University · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Emerging antibiotic resistance in Gram-negative pathogensR01AI145069 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI YU, EDWARD W · 2019 to 2023
$3.3M
Metabolite modulation of Mtb regulators of cell wall biogenesisR01AI123148 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI PURDY, GEORGIANA E., YU, EDWARD W · 2017 to 2021
$2.4M
Medical Research Council MR/N020413/1NIAID NIH HHS R01 AI123148NIAID NIH HHS R01 AI145069NIGMS NIH HHS P41 GM103403
6 · The paper itself

Abstract

The cell envelope of

Indexed as

Bacterial ProteinsBiological TransportCell MembraneCell WallCord FactorsMembrane Transport ProteinsMycobacterium smegmatisMycolic AcidsPhosphatidylethanolaminesBacterial ProteinsCord FactorsMembrane Transport ProteinsMycolic AcidsphosphatidylethanolaminePhosphatidylethanolaminestrehalose monomycolatecell-wall biogenesisMmpL3 transportermycobacterial membrane protein Largenative mass spectrometryX-ray crystallography

Identifiers

PMID31113875
PMCPMC6561238
OpenAlexW2913841228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.