Evidence map›Paper›PMID 31113860›Full record

ArticleThe Journal of biological chemistry2019

Inorganic polyphosphate accumulation suppresses the dormancy response and virulence in

Prabhakar Tiwari, Tannu Priya Gosain, Mamta Singh, Gaurav D Sankhe, Garima Arora, Saqib Kidwai, Sakshi Agarwal, Saurabh Chugh, Deepak K Saini, Ramandeep Singh

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Two endogenousProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Effects of Polyphosphate on Leukocyte Function.Progress in molecular and subcellular biology · 2022
    Review
  5. Review
  6. Biology · 2021
    Article
  7. Article
  8. Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenicJournal of enzyme inhibition and medicinal chemistry · 2020
    Article
  9. Article
  10. Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Prabhakar TiwariTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Tannu Priya GosainTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Mamta SinghTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Gaurav D SankheCentre for BioSystems Science and Engineering and.
Garima AroraTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Saqib KidwaiTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Sakshi AgarwalTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Saurabh ChughTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and.
Deepak K SainiCentre for BioSystems Science and Engineering and; Department of Molecular Reproduction, Development, and Genetics, Biological Sciences Building, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Ramandeep SinghTuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Haryana 121001, India and. Electronic address: ramandeep@thsti.res.in.
Translational Health Science and Technology Institute · INIndian Institute of Science Bangalore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stringent response pathways involving inorganic polyphosphate (PolyP) play an essential role in bacterial stress adaptation and virulence. The intracellular levels of PolyP are modulated by the activities of polyphosphate kinase-1 (PPK1), polyphosphate kinase-2 (PPK2), and exopolyphosphatases (PPXs). The genome of

Indexed as

Acid Anhydride HydrolasesAnimalsAntitubercular AgentsBacterial ProteinsFemaleGene Expression Regulation, BacterialGuinea PigsMicrobial ViabilityMycobacterium tuberculosisPhosphotransferasesPhosphotransferases (Phosphate Group Acceptor)PolyphosphatesVirulenceAcid Anhydride HydrolasesAntitubercular AgentsBacterial ProteinsexopolyphosphatasePhosphotransferasesPhosphotransferases (Phosphate Group Acceptor)polyphosphate kinasePolyphosphatesbacterial pathogenesisbiofilmdormancy-associated genesexopolyphosphataseshypoxiainorganic polyphosphate homeostasismicrobial pathogenesismicrobiologymolecular biologymycobacteriaMycobacterium tuberculosisstress adaptationvirulence

Identifiers

PMID31113860
PMCPMC6635458
OpenAlexW2945740525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.