Evidence map›Paper›PMID 31113852›Full record

ArticleScience signaling2019

CRAC channels regulate astrocyte Ca

Anna B Toth, Kotaro Hori, Michaela M Novakovic, Natalie G Bernstein, Laurie Lambot, Murali Prakriya

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
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  6. STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
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  10. Article
  11. Review
  12. Review
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  15. High-Frequency Imaging Reveals Synchronised Delta- and Theta-Band CaInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. SOCE as a regulator of neuronal activity.The Journal of physiology · 2024
    Review
  18. Article
  19. Store-operated calcium entry in the satellite glial cells of rat sympathetic ganglia.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  20. Astrocyte-specific CaBiochemistry and cell biology = Biochimie et biologie cellulaire · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anna B TothDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-7505-6207
Kotaro HoriDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-1382-0369
Michaela M NovakovicDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Natalie G BernsteinDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-5347-749X
Laurie LambotDepartment of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-8417-5021
Murali PrakriyaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. m-prakriya@northwestern.edu.ORCID 0000-0003-0781-4480
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Regulation of neural progenitor cell migration by store-operated CRAC channelsR01NS094011 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MILLER, RICHARD J, PRAKRIYA, MURALI · 2015 to 2018
$1.3M
Activation Mechanisms of Store-Operated Calcium ChannelsR01GM114210 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2015 to 2018
$1.2M
Store-operated channels in the nervous systemR56NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2012 to 2012
$344k
REGULATION OF GLIOTRANSMISSION BY STORE-OPERATED CALCIUM CHANNELSF30NS090817 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOTH, ANNA B. · 2016 to 2018
$125k
NCI NIH HHS P30 CA060553NIA NIH HHS T32 AG020506NIGMS NIH HHS R01 GM114210NINDS NIH HHS F30 NS090817NINDS NIH HHS R01 NS057499NINDS NIH HHS R01 NS094011NINDS NIH HHS R56 NS057499
6 · The paper itself

Abstract

Astrocytes are the major glial subtype in the brain and mediate numerous functions ranging from metabolic support to gliotransmitter release through signaling mechanisms controlled by Ca

Indexed as

Adenosine TriphosphateAnimalsAstrocytesCA1 Region, HippocampalCalciumCalcium Release Activated Calcium ChannelsCalcium SignalingCells, CulturedExocytosisFemaleGABAergic NeuronsMaleMice, Inbred C57BLMice, KnockoutMice, TransgenicORAI1 ProteinAdenosine TriphosphateCalciumCalcium Release Activated Calcium ChannelsORAI1 ProteinStromal Interaction Molecule 1

Identifiers

PMID31113852
PMCPMC6837172
OpenAlexW2946711439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.