ArticleCancer research2019
Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
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31citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 10% of its field
What it found
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Abnormal body weight and risk of gallbladder cancer: an updated meta-analysis incorporating recent evidence.BMC cancer · 2026Pooled it
- Dietary intake, obesity, and physical activity in association with biliary tract cancer risk: Results from meta-analyses of individual-level data from prospective cohort studies of 723,326 adults.International journal of cancer · 2024Pooled it
- Waist to height ratio as a simple tool for predicting mortality: a systematic review and meta-analysis.International journal of obesity (2005) · 2023Pooled it
- Laparoscopic Pancreaticoduodenectomy in Elderly Patients: Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Global burden landscape (1990-2021) of gallbladder and biliary tract cancer attributable to high body mass index in older adults and a projection to 2050.Journal of gastrointestinal oncology · 2026Article
- Article
- Establishing cancer registries in Africa - focus on hepatopancreatobiliary cancers.Nature reviews. Gastroenterology & hepatology · 2026Review
- Obesity and Cancer: Mechanisms, Epidemiological Evidence, and Potential Risk Reduction.Journal of obesity & metabolic syndrome · 2026Review
- The increasing burden of early-onset pancreatic and biliary tract cancers: a review of risk factors.ESMO gastrointestinal oncology · 2025Review
- Associations between prediagnostic plasma metabolites and biliary tract cancer risk in the prospective UK Biobank cohort.American journal of epidemiology · 2025Article
- Trends and projections of gallbladder and biliary tract cancer in China: a comprehensive analysis from 1990 to 2030 based on the Global Burden of Disease Study 2021.BMC public health · 2025Article
- Association between relative fat mass and female infertility among reproductive-aged women from NHANES 2013-2020.Scientific reports · 2025Article
- Interplay of Cardiometabolic Syndrome and Biliary Tract Cancer: A Comprehensive Analysis with Gender-Specific Insights.Cancers · 2024Review
- Association between visceral adiposity index and infertility in reproductive-aged women in the United States.Scientific reports · 2024Article
- Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium.International journal of cancer · 2024Article
- Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones.Future science OA · 2024Article
- Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy.Frontiers in immunology · 2023Review
- Higher waist circumference is associated with increased likelihood of female infertility: NHANES 2017-2020 results.Frontiers in endocrinology · 2023Article
- Gallbladder cancer.Nature reviews. Disease primers · 2022Review
- A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer.Hepatology communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 20 institutions in 8 countries.
Sarah S JacksonDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland. sarah.jackson@nih.gov.ORCID 0000-0001-6986-8842
Alison L Van DykeDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Bin ZhuDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0001-7791-2698
Jessica L PetrickDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Amy Berrington de GonzálezDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Andrew T ChanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Yu ChenDepartment of Population Health and Perlmutter Cancer Center, New York University School of Medicine, New York, New York.
Gary E FraserSchool of Public Health, Loma Linda University, Loma Linda, California.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Susan M GapsturBehavioral and Epidemiology Research Group, American Cancer Society, Inc., Atlanta, Georgia.
J Michael GazianoDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0003-4946-9099
Eric J GrantDepartment of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.ORCID 0000-0002-6921-8329
Francine GrodsteinDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Mazda JenabSection of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Synnove F KnutsenSchool of Public Health, Loma Linda University, Loma Linda, California.
Woon-Puay KohHealth Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Susanna C LarssonUnit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0118-0341
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, Indiana.
Emma E McGeeDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0002-7456-6408
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0001-5764-7268
Kristine R MonroeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-3016-2081
Marian L NeuhouserCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0002-1931-1349
Ulrike PetersCancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jenny N PoynterDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-8460-3938
Mark P PurdueDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Kim RobienExercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia.ORCID 0000-0002-2120-2280
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0002-6776-0018
Norie SawadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Catherine SchairerDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-9698-9954
Tracey G SimonDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-0610-5287
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Renwei WangUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Elisabete WeiderpassInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0003-2237-0128
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0002-3834-1535
Emily WhiteDepartment of Epidemiology, University of Washington, Seattle, Washington.
Alicja WolkUnit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Jian-Min YuanUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Anne Zeleniuch-JacquotteDepartment of Population Health and Perlmutter Cancer Center, New York University School of Medicine, New York, New York.
Xuehong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Inc., Atlanta, Georgia.
Jill KoshiolDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Cancer Genetics (United States) · USBrigham and Women's Hospital · USAmerican Cancer Society · USCentre international de recherche sur le cancer · FRKarolinska Institutet · SELoma Linda University · USNational Institute of Environmental Health Sciences · USNew York University · USPrevention Group · USThe University of Melbourne · AUUniversity of Washington · USFred Hutch Cancer Center · USIndiana University Bloomington · USMassachusetts General Hospital · USMilken Institute · USOsloMet – Oslo Metropolitan University · NORadiation Effects Research Foundation · JPShanghai Cancer Institute · CNSingHealth · SGUniversity of Minnesota · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FUCHS, CHARLES S · 1991 to 2009
$41.8MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1MEnvironmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MEPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0MBritish Heart FoundationCancer Research UKDepartment of HealthIntramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049030Intramural NIH HHS Z99 CA999999Medical Research CouncilNCI NIH HHS HHSN261201500005CNCI NIH HHS HHSN268201600002CNCI NIH HHS K05 CA154337NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA043092NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA144034NCI NIH HHS U01 CA152939NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA182934NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIEHS NIH HHS P30 ES000260Wellcome TrustWorld Health Organization 001
Abstract
Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m
Indexed as
AnthropometryBiliary Tract NeoplasmsFemaleHumansMaleMiddle AgedProspective StudiesRisk Factors
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