Evidence map›Paper›PMID 31113746›Full record

ArticleSchizophrenia research2019

Differential gene expression analysis in blood of first episode psychosis patients.

Daniel J Leirer, Conrad O Iyegbe, Marta Di Forti, Hamel Patel, Elena Carra, Sara Fraietta, Marco Colizzi, Valeria Mondelli, Diego Quattrone, John Lally and 10 more

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In one paragraph

Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Daniel J LeirerMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK. Electronic address: k1184970@kcl.ac.uk.
Conrad O IyegbeDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Marta Di FortiMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.
Hamel PatelMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.
Elena CarraDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Sara FraiettaDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Marco ColizziDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Valeria MondelliDepartment of Psychological Medicine, Institute of Psychiatry, Kings College London, De Crespigny Park, SE5 8AF London, UK.
Diego QuattroneMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.
John LallyDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Olesya AjnakinaDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Sang Hyuck LeeMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London.
Charles J CurtisMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London.
Gerome BreenMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London.
Carmine ParianteDepartment of Psychological Medicine, Institute of Psychiatry, Kings College London, De Crespigny Park, SE5 8AF London, UK.
Katherine AitchisonDepartments of Psychiatry and Medical Genetics, University of Alberta, 11361-87 Avenue, AB T6G 2E1, Edmonton, Canada.
Paola DazzanMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; Department of Psychological Medicine, Institute of Psychiatry, Kings College London, De Crespigny Park, SE5 8AF London, UK.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Kings College London, Box P092, De Crespigny Park, SE5 8AF London, UK.
Richard J B DobsonNIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.
Stephen J NewhouseMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, Box P080, De Crespigny Park, SE5 8AF London, UK.
King's College London · GBPsychiatry Research Trust · GBUniversity of Alberta · CA

Funding

Department of Health PDF-2018-11-ST2-020Medical Research Council G108/603Medical Research Council MC_PC_17214Medical Research Council MR/M008436/1
6 · The paper itself

Abstract

backgroundPsychosis is a condition influenced by an interaction of environmental and genetic factors. Gene expression studies can capture these interactions; however, studies are usually performed in patients who are in remission. This study uses blood of first episode psychosis patients, in order to characterise deregulated pathways associated with psychosis symptom dimensions.

methodsPeripheral blood from 149 healthy controls and 131 first episode psychosis patients was profiled using Illumina HT-12 microarrays. A case/control differential expression analysis was performed, followed by correlation of gene expression with positive and negative syndrome scale (PANSS) scores. Enrichment analyses were performed on the associated gene lists. We test for pathway differences between first episode psychosis patients who qualify for a Schizophrenia diagnosis against those who do not.

resultsA total of 978 genes were differentially expressed and enriched for pathways associated to immune function and the mitochondria. Using PANSS scores we found that positive symptom severity was correlated with immune function, while negative symptoms correlated with mitochondrial pathways.

conclusionsOur results identified gene expression changes correlated with symptom severity and showed that key pathways are modulated by positive and negative symptom dimensions.

Indexed as

TranscriptomeAdolescentAdultAffective Disorders, PsychoticBipolar DisorderCase-Control StudiesDepressive DisorderFemaleGene Expression ProfilingGene OntologyHumansMaleOligonucleotide Array Sequence AnalysisPsychotic DisordersRNASchizophreniaRNAAnti-psychotic medicationFirst episode psychosisGene expressionImmune systemPANSSTranscriptome

Identifiers

PMID31113746
PMCPMC6677921
OpenAlexW2945822310

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.