Evidence map›Paper›PMID 31113675›Full record

ArticleVaccine2019

Comparison of a frailty short interview to a validated frailty index in adults hospitalized for acute respiratory illness.

Joshua G Petrie, Emily T Martin, Yuwei Zhu, Dayna G Wyatt, Anne Kaniclides, Jill M Ferdinands, Arnold S Monto, Christopher Trabue, H Keipp Talbot

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua G PetrieDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, United States. Electronic address: jpetrie@umich.edu.
Emily T MartinDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, United States.
Yuwei ZhuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Dayna G WyattDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Anne KaniclidesDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, United States.
Jill M FerdinandsInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Arnold S MontoDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, United States.
Christopher TrabueDepartment of Medicine, University of Tennessee Health Science Center, Saint Thomas Health, Nashville, TN, United States.
H Keipp TalbotDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States; Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

NCIRD CDC HHS U01 IP000974NCIRD CDC HHS U01 IP000979
6 · The paper itself

Abstract

backgroundFrailty is an important physiologic factor in studies of influenza and influenza vaccines carried out in older adults and hospitalized populations. Unfortunately, comprehensive assessments of frailty requiring physical assessments and extensive medical record review are not often feasible in time- and resource-limited settings common to studies of influenza and influenza vaccines.

methodsWe developed a 5-question frailty short interview, and implemented it in a multicenter, hospital-based study of influenza over two years. Frailty status defined by the frailty short interview was compared to a validated frailty index based on medical record review of 59 parameters. Agreement between the two frailty measures was assessed, and multivariable linear regression models were used to explore differences between the measures. The association between each frailty measure and likelihood of influenza vaccination was also assessed.

resultsDuring the 2015-2016 and 2016-2017 influenza seasons, 2070 adult patients hospitalized with acute respiratory illness were enrolled and included in analyses. Frailty was frequently identified in the study population; 43% of participants were defined as frail by the frailty short interview and 32% by frailty index. Responses to the frailty short interview were only moderately correlated with the frailty index, and agreement between the two frailty measures was low. Women were more likely to be defined as frail by the frailty short interview than men. White individuals were more likely than other races to be defined as frail by the frailty index. Increasing frailty index was associated with increased likelihood of influenza vaccination, but the frailty short interview was not associated with vaccination.

conclusionsThe frailty short interview provided a feasible and consistent measure of frailty across study hospitals and study years. However, its modest correlation with the frailty index and differential association with likelihood of influenza vaccination highlight differences in the conceptualization of frailty.

Indexed as

Acute DiseaseAdolescentAdultAgedAged, 80 and overFemaleFrailtyHospitalizationHumansInfluenza, HumanInfluenza VaccinesLinear ModelsMaleMedical RecordsMiddle AgedRespiratory Tract DiseasesInfluenza VaccinesAdultsFrailtyHospitalizationInfluenzaInfluenza vaccination

Identifiers

PMID31113675
PMCPMC8564875

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.