Evidence map›Paper›PMID 31113464›Full record

ReviewItalian journal of pediatrics2019

Vernal Keratoconjunctivitis: an update focused on clinical grading system.

A M Zicari, G Capata, M Nebbioso, G De Castro, F Midulla, L Leonardi, L Loffredo, A Spalice, L Perri, M Duse

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Review
  5. Grading Scales of Conjunctival Inflammation.Diagnostics (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

A M ZicariDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
G CapataDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy. giulia.capata@gmail.com.
M NebbiosoDepartment of Sense Organs, "Sapienza" University of Rome, Rome, Italy.
G De CastroDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
F MidullaDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
L LeonardiDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
L LoffredoDepartment of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Rome, Italy.
A SpaliceDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
L PerriDepartment of Internal Medicine and Medical Specialities, "Sapienza" University of Rome, Rome, Italy.
M DuseDepartment of Pediatrics, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVernal keratoconjunctivitis (VKC) is a severe disease with a prevalence of < 1 case out of 10,000 in Europe, which occurs mainly in pediatric age and is characterized by a severe and often bilateral chronic inflammation of the ocular surface. The diagnosis is generally confirmed by the finding at the ocular examination of conjunctival hyperemia, papillary hypertrophy in the tarsal conjunctiva, giant papillae, papillae in the limbus region.

objectiveAim of this review is to provide an updated overview on the disease focused on clinical grading system, searching papers published in the last decade on VKC in scientific databases.

resultsCurrently there are no standardized criteria for diagnosis of VKC and there is no uniformity to define disease severity, which makes difficult to diagnose and treat the disease.

conclusionsGiven the wide overlap of the symptoms of VKC with the allergic conjunctivitis, criteria of probable, possible or improbable diagnosis are needed, providing pediatricians with parameters useful for deciding whether to drive the patient to the ophthalmologist for diagnostic confirmation.

Indexed as

ChildConjunctivitis, AllergicDiagnosis, DifferentialHumansClinical markersDiagnosisGradingVernal keratoconjunctivitis

Identifiers

PMID31113464
PMCPMC6528205
OpenAlexW2945803300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.