ArticleBMC cancer2019
Prognostic value of lymphovascular invasion in patients with squamous cell carcinoma of the penis following surgery.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Oncologic outcomes and prognostic significance of lymphovascular invasion in renal cell carcinoma according to nodal stage.International urology and nephrology · 2026Article
- Outcomes of Adjuvant Radiation Therapy in Penile Cancer.Advances in radiation oncology · 2026Article
- Unveiling the variations in penile cancer care: identifying knowledge gaps and research priorities.BMJ oncology · 2026Review
- Molecular Pathways and Biomarkers in Endometrial Carcinoma: Paving the Way for Precision Medicine.Anti-cancer agents in medicinal chemistry · 2026Review
- Tertiary lymphoid structures in genitourinary cancers: a comprehensive review.Frontiers in oncology · 2026Review
- A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma.BMC urology · 2024Article
- Article
- Clinical Profile and Predictors of Survival in Carcinoma Penis Patients.Current oncology (Toronto, Ont.) · 2023Article
- A machine learning-based model for predicting the risk of early-stage inguinal lymph node metastases in patients with squamous cell carcinoma of the penis.Frontiers in surgery · 2023Article
- The clinicopathological and microrna expression signature associated with lymphovascular invasion in squamous cell carcinoma: A basic descriptive study.Health science reports · 2022Article
- Tumor Location May Independently Predict Survival in Patients With M0 Squamous Cell Carcinoma of the Penis.Frontiers in oncology · 2022Article
- The prognostic significance of primary tumor size in squamous cell carcinoma of the penis.Discover oncology · 2021Article
- What you need to know: updates in penile cancer staging.World journal of urology · 2021Review
- Comparing T2-T3 staging of penile cancer according to the American Joint Committee on cancer 8Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
- Novel Prognostic Models for Patients With Penile Carcinoma.Cancer control : journal of the Moffitt Cancer CenterArticle
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7 authors.
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Abstract
backgroundTo evaluate the prognostic value of Lymphovascular Invasion (LVI) in patients with squamous cell carcinoma of the penis (SCCP) following surgery. PATIENTS AND
methodsThis retrospective study analyzed the data of 891 eligible patients with SCCP who were diagnosed between 2010 and 2014, obtained from the Surveillance, Epidemiology, and End Results (SEER) database. The patients were categorized by LVI, age, grade, T stage, lymph nodes status, distant metastasis, regional lymph nodes removed, and surgery. Overall survival (OS) and penile carcinoma-specific survival (PCSS) were evaluated by Kaplan-Meier method and Cox proportional hazards regression model.
resultsThe presence of LVI was significantly associated with increased risk of advanced T stage, high grade, lymph node metastasis, and distant metastasis (P < 0.001 for all). In Kaplan-Meier analyses, patients with the presence of LVI had significantly lower OS and PCSS than those with the absence of LVI (P < 0.001 for both,). The presence of LVI was also significantly associated with poorer OS and worse PCSS in patients with Tx + Ta + T1 stage (P = 0.007, P < 0.001), N0 stage (P < 0.001, P = 0.040), grade 1 (P = 0.001, P < 0.001), grade 2 (P = 0.001, P = 0.014), no distant metastasis (P < 0.001 for both), no regional lymph nodes removed (P < 0.001 for both), Non-radical surgery (P < 0.001 for both) and radical surgery(P = 0.037, P = 0.002). In multivariate analyses, the presence of LVI in patients with SCCP following surgery was found to be a significant independent predictor of decreased OS (hazard ratio 1.403, P = 0.039).
conclusionsThe LVI status might be a crucial prognostic indicator for overall survival in patients with SCCP.
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