ArticleBMC medical genetics2019
Gene spectrum analysis of thalassemia for people residing in northern China.
Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia.Nature communications · 2025Article
- Genetic Analysis of Alpha-Thalassemia Mutations in Thi-Gar Province, Iraq.Archives of Razi Institute · 2022Article
- Prevalence and molecular characterization of alpha and beta-Thalassemia mutations among Hakka people in southern China.Genetics and molecular biology · 2022Article
- Genotypes of thalassemia in children: an analysis of 30 417 cases.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Molecular basis and diagnosis of thalassemia.Blood research · 2021Review
- [Rare thalassemia caused by novel nucleotide variants in the globin gene: four case reports and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSouthern China provinces have high incidence of thalassemia, however, sporadic cases can be found in northern China as well.
methodsPeople resided in north China who were suspected to have thalassemia were detected mutations by gap-polymerase chain reaction (Gap-PCR) and reverse dot blot (RDB) analyses. Those with positive findings from 2012 to 2017 were further analyzed for basic clinical data and ancestral information either by medical records or by telephone follow-up or both.
resultsMost people enrolled in our study had no or mild symptoms. For those with positive gene findings, people originated from the north had higher percentage of β-thalassemia gene mutations compared with those originated from the south (72.8% vs. 62.4%, χ
conclusionMost of people in north China with thalassemia mutation gene were thalassemia carriers. People originated from the north had higher frequency of β mutation than those originated from the south, but the north people had similar individual gene mutation profile compared with south people both for α and β mutations. People lived in different altitudes had different spectrum of β mutations.
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