Evidence map›Paper›PMID 31113375›Full record

ArticleBMC infectious diseases2019

The TransFLUas influenza transmission study in acute healthcare - recruitment rates and protocol adherence in healthcare workers and inpatients.

Hila Schwarz, Jürg Böni, Roger D Kouyos, Teja Turk, Edouard Battegay, Malcolm Kohler, Rouven Müller, Heidi Petry, Hugo Sax, Rainer Weber and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02478905 (TransFLUas), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02478905 completednot on this map

TransFLUas: Transmission of Influenza Virus From Asymptomatic Healthcare Workers and Inpatients in the Acute Care Hospital Setting: A Prospective Study Over Two Consecutive Influenza Seasons

Typeobservational_patient_registrySponsorUniversity of ZurichRan2016 to 2017Enrolled700ConditionsHuman InfluenzaArmsInfluenza
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Hila SchwarzDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland.
Jürg BöniInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Roger D KouyosDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland.
Teja TurkDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland.
Edouard BattegayDepartment of Internal Medicine, University Hospital and University of Zurich, Zurich, Switzerland.
Malcolm KohlerPulmonary Division, University Hospital and University of Zurich, Zurich, Switzerland.
Rouven MüllerHematology, University Hospital and University of Zurich, Zurich, Switzerland.
Heidi PetryUniversity Hospital Zurich, Zurich, Switzerland.
Hugo SaxDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland.
Rainer WeberDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland.
Allison McGeerDepartment of Microbiology, Sinai Health System, Toronto, Canada.
Alexandra TrkolaInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Stefan P KusterDivision of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Raemistrasse 100 / HAL14 D6, 8091, Zürich, Switzerland. stefan.kuster@usz.ch.ORCID http://orcid.org/0000-0002-0525-6529
University of Zurich · CHSinai Health System · CAUniversity Hospital of Zurich · CH

Funding

Bundesamt für Gesundheit (CH) 16.927730Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 32003B_156902
6 · The paper itself

Abstract

backgroundDetailed knowledge about viral respiratory disease transmission dynamics within healthcare institutions is essential for effective infection control policy and practice. In the quest to study viral transmission pathways, we aimed to investigate recruitment rates and adherence of healthcare workers (HCWs) and hospital inpatients with a study protocol that involves prospective surveillance based on daily mid-turbinate nasal swabs and illness diaries.

methodsSingle center prospective surveillance of patients and HCWs in three different hospital departments of a tertiary care center during an entire influenza season in Switzerland. Inpatients and acute care HCWs were asked to provide mid-turbinate nasal swabs and illness diaries on a daily basis. Study protocol adherence and recruitment rates were the primary outcomes of interest.

resultsA total 251 participants (59 (23.5%) health care workers and 192 (76.5%) inpatients) were recruited from three different hospital wards. Recruitment rates differed between HCWs (62.1% of eligible HCWs) and inpatients (32.5%; P < 0.001), but not within HCWs (P = 0.185) or inpatients (P = 0.301) of the three departments. The total number of study-days was 7874; 2321 (29.5%) for inpatients and 5553 (70.5%) for HCWs. HCWs were followed for a median of 96 days (range, 71-96 days) and inpatients for 8 days (range, 3-77 days). HCWs provided swabs on 73% (range, 0-100%) of study days, and diaries on 77% (range 0-100%). Inpatients provided swabs and diaries for 83% (range, 0-100%) of days in hospital. In HCWs, increasing age, working in internal medicine and longer duration of total study participation were positively associated with the proportion of swabs and diaries collected. Adherence to the study protocol was significantly lower in physicians as compared to nurses for both swabs (P = 0.042) and diaries (P = 0.033). In inpatients, no association between demographic factors and adherence was detected. Conclusions Prospective surveillance of respiratory viral disease was feasible in a cohort of inpatients and HCWs over an entire influenza season, both in terms of recruitment rates and adherence to a study protocol that included daily specimen collection and illness diaries.

trial registrationclinicaltrials.gov NCT02478905 . Date of registration June 23, 2015.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGuideline AdherenceHealth PersonnelHumansInfluenza, HumanInpatientsMaleMiddle AgedProspective StudiesSwitzerlandAsymptomatic infectionHealthcare-associated infectionInfluenzaSurveillanceTransmission

Identifiers

PMID31113375
PMCPMC6528321
OpenAlexW2947878608

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.