ArticleBMC evolutionary biology2019
Immunogenetic response of the bananaquit in the face of malarial parasites.
Article in BMC evolutionary biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Reduced Offspring Viability Is Associated With Long-Term Stability of a Narrow Avian Hybrid Zone.Ecology and evolution · 2025Article
- Higher body condition with infection byPeerJ · 2024Article
- Leveraging an existing whole-genome resequencing population data set to characterize toll-like receptor gene diversity in a threatened bird.Molecular ecology resources · 2022Article
- Management of avian malaria in populations of high conservation concern.Parasites & vectors · 2022Review
- Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors.Molecular biology and evolution · 2022Review
- Genetic drift and bottleneck do not influence diversity in Toll-like receptor genes at a small spatial scale in a Himalayan passerine.Ecology and evolution · 2020Article
- Extremely low malaria prevalence in a wetland specialist passerine.Parasitology · 2020Article
- Episodic positive diversifying selection on key immune system genes in major avian lineages.Genetica · 2019Article
- Immunogenetic response of the bananaquit in the face of malarial parasites.BMC evolutionary biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the arms race between hosts and parasites, genes involved in the immune response are targets for natural selection. Toll-Like Receptor (TLR) genes play a role in parasite detection as part of the innate immune system whereas Major Histocompatibility Complex (MHC) genes encode proteins that display antigens as part of the vertebrate adaptive immune system. Thus, both gene families are under selection pressure from pathogens. The bananaquit (Coereba flaveola) is a passerine bird that is a common host of avian malarial parasites (Plasmodium sp. and Haemoproteus sp.). We assessed molecular variation of TLR and MHC genes in a wild population of bananaquits and identified allelic associations with resistance/susceptibility to parasitic infection to address hypotheses of avian immune response to haemosporidian parasites.
resultsWe found that allele frequencies are associated with infection status at the immune loci studied. A consistent general trend showed the infected groups possessed more alleles at lower frequencies, and exhibited unique alleles, compared to the uninfected group.
conclusionsOur results support the theory of natural selection favoring particular alleles for resistance while maintaining overall genetic diversity in the population, a mechanism which has been demonstrated in some systems in MHC previously but understudied in TLRs.
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