Evidence map›Paper›PMID 31112694›Full record

ArticleDevelopmental cell2019

Autophagy Keeps the Balance in Tissue Homeostasis.

Michael Buszczak, Helmut Krämer

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael BuszczakDepartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: michael.buszczak@utsouthwestern.edu.
Helmut KrämerDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA; Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: helmut.kramer@utsouthwestern.edu.
Southwestern Medical Center · US

Funding

MOLECULAR ANALYSIS OF THE BOSS TRANSMEMBRANE LIGANDR01EY010199 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI Helmut J Kramer · 1994 to 2026
$9.7M
Endocytic Trafficking and Cell Signaling in Models of ARC SyndromeR01GM120196 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI KRAMER, HELMUT J · 2017 to 2020
$1.3M
NEI NIH HHS R01 EY010199NIGMS NIH HHS R01 GM120196
6 · The paper itself

Abstract

Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of Developmental Cell, Zhang and colleagues (2019) show autophagy-mediated regulation of EGFR signaling cell autonomously controls intestinal stem cell proliferation, with implications for human colorectal cancer development.

Indexed as

AutophagyCell DifferentiationCell ProliferationErbB ReceptorsHomeostasisHumansStem CellsEGFR protein, humanErbB Receptors

Identifiers

PMID31112694
OpenAlexW2946640128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.