ArticleInflammatory bowel diseases2019
Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis.
Article in Inflammatory bowel diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Characterizing the gut virome in ulcerative colitis and crohn's disease: signatures of disease severity.Virology journal · 2026Observational
- The effects of stress on gut virome: Implications on infectious disease and systemic disorders.MicrobiologyOpen · 2024Review
- Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.Microbiome · 2024Article
- Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor.Immunity, inflammation and disease · 2024Review
- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
- Validation of the VirCapSeq-VERT system for differential diagnosis, detection, and surveillance of viral infections.Journal of clinical microbiology · 2024Article
- Children with autism show differences in the gut DNA virome compared to non-autistic children: a case control study.BMC pediatrics · 2023Article
- Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis.International journal of molecular sciences · 2021Review
- Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases.Gastroenterology · 2021Review
- Enteric Viruses and Inflammatory Bowel Disease.Viruses · 2021Review
- Review
- Virome Sequencing of the Human Intestinal Mucosal-Luminal Interface.Frontiers in cellular and infection microbiology · 2020Article
- Article
Corrections and comments
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Authors and funding
21 authors at 13 institutions in 2 countries.
Funding
Abstract
backgroundViral infections have been suggested as possible triggers for the onset of ulcerative colitis (UC).
methodsWe employed VirCapSeq-Vert, a high-throughput sequencing virus capture platform, to examine the stool virome of children with newly diagnosed moderate to severe UC. We surveyed fecal samples collected at presentation, after symptom remission, and from a control group diagnosed with irritable bowel syndrome.
resultsSeventy subjects with UC (mean age 13 years, 45 had moderate symptoms, 25 had severe, 69 of 70 had a Mayo endoscopy subscore 2/3) were studied. We detected a wide range of animal viruses that were taxonomically classified into 12 viral families. A virus was present in 50% of fecal samples collected at presentation, 41% of samples collected after remission, and 40% of samples in our control group. The most frequently identified viruses were diet-based gyroviruses. The UC cohort had a significantly higher prevalence of anelloviruses compared with the control cohort. However, we did not identify a single virus that can be implicated in the onset of UC and did not find an association between UC disease severity and viral presence.
conclusionPresence of virus in stool was not associated with the onset of pediatric UC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.