Evidence map›Paper›PMID 31112592›Full record

ArticleAmerican journal of hypertension2019

Ethnic Differences in Nighttime Melatonin and Nighttime Blood Pressure: A Study in European Americans and African Americans.

Jinhee Jeong, Haidong Zhu, Ryan A Harris, Yanbin Dong, Shaoyong Su, Martha S Tingen, Gaston Kapuku, Jennifer S Pollock, David M Pollock, Gregory A Harshfield and 1 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  4. Observational
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jinhee JeongDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Haidong ZhuDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Ryan A HarrisDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Yanbin DongDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Shaoyong SuDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Martha S TingenDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Gaston KapukuDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Jennifer S PollockCardio Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David M PollockCardio Renal Physiology and Medicine Section, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gregory A HarshfieldDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Xiaoling WangDepartment of Population Health Sciences, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Prevention Institute · USAugusta University · USUniversity of Alabama at Birmingham · US

Funding

Vascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
NHLBI NIH HHS P01 HL069999NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundEthnic differences in nighttime blood pressure (BP) have long been documented with African Americans (AAs) having higher BP than European Americans (EAs). At present, lower nighttime melatonin, a key regulator of circadian rhythms, has been associated with higher nighttime BP levels in EAs. This study sought to test the hypothesis that AAs have lower nighttime melatonin secretion compared with EAs. We also determined if this ethnic difference in melatonin could partially explain the ethnic difference in nighttime BP.

methodsA total of 150 young adults (71 AA; 46% females; mean age: 27.7 years) enrolled in the Georgia Stress and Heart study provided an overnight urine sample for the measurement of 6-sulfatoxymelatonin, a major metabolite of melatonin. Urine melatonin excretion (UME) was calculated as the ratio between 6-sulfatoxymelatonin concentration and creatinine concentration. Twenty-four-hour ambulatory BP was assessed and nighttime systolic BP (SBP) was used as a major index of BP regulation.

resultsAfter adjustment of age, sex, body mass index, and smoking, AAs had significantly lower UME (P = 0.002) and higher nighttime SBP than EAs (P = 0.036). Lower UME was significantly associated with higher nighttime SBP and this relationship did not depend on ethnicity. The ethnicity difference in nighttime SBP was significantly attenuated after adding UME into the model (P = 0.163).

conclusionThis study is the first to document the ethnic difference in nighttime melatonin excretion, demonstrating that AAs have lower melatonin secretion compared with EAs. Furthermore, the ethnic difference in nighttime melatonin can partially account for the established ethnic difference in nighttime SBP.

Indexed as

Black or African AmericanBlood PressureCircadian RhythmHealth Status DisparitiesWhite PeopleAdultBiomarkersFemaleGeorgiaHumansHypertensionMaleMelatoninRace FactorsRisk FactorsTime FactorsBiomarkersMelatoninAfrican Americansblood pressureethnic differencehypertensionmelatoninnighttime blood pressure

Identifiers

PMID31112592
PMCPMC6758939
OpenAlexW2944982598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.