ArticlePloS one2019
FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Hyperfunction of post-synaptic density protein 95 promotes seizure response in early-stage aβ pathology.EMBO reports · 2024Article
- G-Quadruplexes Regulate miRNA Biogenesis in Live Zebrafish Embryos.International journal of molecular sciences · 2023Article
- Increased Serum Levels of miR-125b and miR-132 in Fragile X Syndrome: A Preliminary Study.Neurology. Genetics · 2022Article
- Interaction between non-coding RNAs, mRNAs and G-quadruplexes.Cancer cell international · 2022Review
- Article
- G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches.JACS Au · 2021Review
- Axonal mRNA localization and local translation in neurodegenerative disease.Neural regeneration research · 2021Review
- G-Quadruplexes as pathogenic drivers in neurodegenerative disorders.Nucleic acids research · 2021Review
- An "Omic" Overview of Fragile X Syndrome.Biology · 2021Review
- RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity.Cellular and molecular life sciences : CMLS · 2021Article
- Article
- RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein.Journal of molecular biology · 2020Article
- Reactivation of FMR1 gene expression is a promising strategy for fragile X syndrome therapy.Gene therapy · 2020Review
- The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.Nucleic acids research · 2020Article
- Urine microRNA Profiling Displays miR-125a Dysregulation in Children with Fragile X Syndrome.Cells · 2020Article
- FUS Recognizes G Quadruplex Structures Within Neuronal mRNAs.Frontiers in molecular biosciences · 2020Article
- The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".Frontiers in genetics · 2019Review
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Fragile X syndrome, the most common inherited form of intellectual disability, is caused by the CGG trinucleotide expansion in the 5'-untranslated region of the Fmr1 gene on the X chromosome, which silences the expression of the fragile X mental retardation protein (FMRP). FMRP has been shown to bind to a G-rich region within the PSD-95 mRNA, which encodes for the postsynaptic density protein 95, and together with microRNA-125a to mediate the reversible inhibition of the PSD-95 mRNA translation in neurons. The miR-125a binding site within the PSD-95 mRNA 3'-untranslated region (UTR) is embedded in a G-rich region bound by FMRP, which we have previously demonstrated folds into two parallel G-quadruplex structures. The FMRP regulation of PSD-95 mRNA translation is complex, being mediated by its phosphorylation. While the requirement for FMRP in the regulation of PSD-95 mRNA translation is clearly established, the exact mechanism by which this is achieved is not known. In this study, we have shown that both unphosphorylated FMRP and its phosphomimic FMRP S500D bind to the PSD-95 mRNA G-quadruplexes with high affinity, whereas only FMRP S500D binds to miR-125a. These results point towards a mechanism by which, depending on its phosphorylation status, FMRP acts as a switch that potentially controls the stability of the complex formed by the miR-125a-guided RNA induced silencing complex (RISC) and PSD-95 mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.