Evidence map›Paper›PMID 31112493›Full record

ArticleJournal of hospital medicine2019

Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis.

Paul L Aronson, Andrea T Cruz, Stephen B Freedman, Fran Balamuth, Kendra L Grether-Jones, Todd W Lyons, Alesia H Fleming, Jeffrey Louie, Rakesh D Mistry, Aris C Garro and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of hospital medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 2 countries.

Paul L AronsonSection of Pediatric Emergency Medicine, Departments of Pediatrics and of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut.
Andrea T CruzSections of Pediatric Emergency Medicine and of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Department of Pediatrics, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta.
Fran BalamuthDivision of Emergency Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Kendra L Grether-JonesDepartment of Emergency Medicine, University of California Davis School of Medicine, Sacramento, California.
Todd W LyonsDivision of Emergency Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Alesia H FlemingDivision of Pediatric Emergency Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Jeffrey LouieDivision of Pediatric Emergency Medicine, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota.
Rakesh D MistryDivision of Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Aris C GarroSection of Emergency Medicine, Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Samir S ShahDivisions of Infectious Diseases and.
Lise E NigrovicDivision of Emergency Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Pediatric Emergency Medicine Clinical Research Network (PEM CRC) Herpes Simplex Virus (HSV) Study Group
Boston Children's Hospital · USBaylor College of Medicine · USBrown University · USEmory University · USUniversity of Calgary · CAUniversity of California, Davis · USUniversity of Cincinnati Medical Center · USUniversity of Colorado Denver · USUniversity of Minnesota · USUniversity of Pennsylvania · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development and pilot trial of a web-based tool to facilitate shared decision-making with parents of febrile infantsK08HS026006 · AHRQ · YALE UNIVERSITY · PI ARONSON, PAUL L · 2018 to 2020
$460k
AHRQ HHS K08 HS026006NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR test performed, and 46 (0.6% of those tested) had a positive test. Infants who had a CSF HSV PCR test performed had a 23% longer hospital LOS (incident rate ratio 1.23; 95% CI: 1.14-1.33). Targeted CSF HSV PCR testing may mitigate the impact on LOS for low-risk infants.

Indexed as

Emergency Service, HospitalFemaleHerpes SimplexHospitalsHumansInfantInfant, NewbornLength of StayMaleMeningitisPolymerase Chain ReactionPregnancy Complications, InfectiousRetrospective StudiesSimplexvirus

Identifiers

PMID31112493
PMCPMC6686736
OpenAlexW2946439029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.