ArticleThe British journal of radiology2019
Sonographic differentiation of complicated from uncomplicated appendicitis.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04440150 (Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Ultrasound and computed tomography in differentiating between simple and complicated appendicitis in pediatric patients.Pediatric surgery international · 2024Pooled it
- Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis.Pediatric surgery international · 2020Pooled it
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- CLR (CRP to Lymphocytes) Score for Differentiating Simple and Complicated Appendicitis in Pediatric Patients.Journal of clinical medicine · 2026Article
- An FUO patient diagnosed as appendicitis: a case report.BMC infectious diseases · 2024Article
- A Novel Deep Learning Approach for the Automatic Diagnosis of Acute Appendicitis.Journal of clinical medicine · 2024Article
- Associations between Th1-related cytokines and complicated pediatric appendicitis.Scientific reports · 2024Article
- The utility of sonographic signs to diagnose simple and complicated appendicitis in children.Pediatric surgery international · 2023Article
- Gastrointestinal Ultrasound in Emergency Setting.Journal of clinical medicine · 2023Review
- Bacterial pathogens in pediatric appendicitis: a comprehensive retrospective study.Frontiers in cellular and infection microbiology · 2023Review
- The Prognostic Value of Ultrasound Findings in Preoperatively Distinguishing between Uncomplicated and Complicated Types of Pediatric Acute Appendicitis Based on Correlation with Intraoperative and Histopathological Findings.Diagnostics (Basel, Switzerland) · 2022Article
- Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis.Medical sciences (Basel, Switzerland) · 2022Article
- Complicated appendicitis increases the hospital length of stay.Surgery open science · 2022Article
- A concise pathophysiological model of acute appendicitis against the background of the COVID-19 pandemic.Frontiers in pediatrics · 2022Review
- Classification of acute appendicitis (CAA): treatment directed new classification based on imaging (ultrasound, computed tomography) and pathology.International journal of colorectal disease · 2021Review
- CT based Acute Appendicitis Severity Index for acute appendicitis and validate its effectiveness in predicting complicated appendicitis.Emergency radiology · 2021Article
- Accuracy of ultrasonography for differentiating between simple and complex appendicitis in children.Pediatric surgery international · 2021Article
- Article
- Use of gene expression profiling to identify candidate genes for pretherapeutic patient classification in acute appendicitis.BJS open · 2021Article
- Combining Ultrasound with a Pediatric Appendicitis Score to Distinguish Complicated from Uncomplicated Appendicitis in a Pediatric Population.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to differentiate acute uncomplicated and complicated appendicitis, by investigating the correlation between sonographic findings and histological results in different types of paediatric appendicitis.
methodsThis is a retrospective study of 1017 paediatric patients (age < 18 years) who underwent ultrasound by paediatric radiologists before appendicectomy at our institution between 2006 and 2016. Histologically, uncomplicated appendicitis was primarily associated with transmural infiltration of neutrophil granulocytes, while complicated appendicitis was characterised by transmural myonecrosis. Logistic regression analyses were used to investigate the association between sonographic and histological findings.
resultsOut of 566 (56%) male and 451 (44%) female patients with a mean age of 10.7 years, uncomplicated appendicitis was histologically diagnosed in 446 (44%) children and complicated appendicitis was diagnosed in 348 (34%) cases. The following ultrasound findings were significantly associated with complicated appendicitis in multivariate regression: an increased appendiceal diameter (OR = 1.3,
conclusionAbdominal sonography by paediatric radiologists can differentiate between uncomplicated and complicated appendicitis in paediatric patients by using an increased appendiceal diameter, periappendiceal fat inflammation, the presence of an appendicolith and a suspected perforation as discriminatory markers. ADVANCES IN KNOWLEDGE: This paper demonstrates expanded information on ultrasound, which is not only an essential tool for diagnosing appendicitis, but also a key method for distinguishing between different forms of appendicitis when performed by paediatric radiologists. Compared with previous studies, the crucial distinction features in our analysis are 1) the definition of gangrene and not primarily perforation as an acute complicated appendicitis enabling early decision-making by sonography and 2) a large number of patients in a particularly affected age group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.