ArticleEpilepsia2019
Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: A multicenter study of 234 patients.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Pooled it
- Efficacy and safety of laser interstitial thermal therapy versus radiofrequency ablation and stereotactic radiosurgery in the treatment of intractable mesial temporal lobe epilepsy: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Outcomes after laser interstitial thermal ablation for temporal lobe epilepsy: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Progress in TLE treatment from 2003 to 2023: scientific measurement and visual analysis based on CiteSpace.Frontiers in neurology · 2023Pooled it
- Resective, Ablative and Radiosurgical Interventions for Drug Resistant Mesial Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis of Outcomes.Frontiers in neurology · 2021Pooled it
- Beyond the Focus: The Piriform-Entorhinal-Dentate Circuit as a Driver of Network Hyperexcitability in Epilepsy.Epilepsy currents · 2026Article
- Advancing the Paradigm of Temporal Lobe Epilepsy as a Network Disease: The Promise of Biomarkers and Targeted Disease Modification.International journal of molecular sciences · 2026Review
- The Tale of the Residual Tail: Insights From Continuous Intracranial Monitoring From Post-Hippocampectomy Dynamics.Annals of clinical and translational neurology · 2026Article
- From competition to complementarity: narrative review of laser interstitial thermal therapy, focused ultrasound, and radiofrequency ablation in minimally invasive neurosurgery.Annals of medicine and surgery (2012) · 2026Review
- Clinical outcomes and learning curve of MRgLITT system for drug-resistant epilepsy in China: A single-center retrospective study.Epilepsia open · 2026Article
- Mesial temporal lobe epilepsy with hippocampal sclerosis: Seizure, neuropsychological, and quality of life outcomes of 100 patients treated with trans-anterior T1 selective amygdalohippocampectomy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Epileptogenesis and Epilepsy Treatment: Advances in Mechanistic Understanding, Therapeutic Approaches, and Future Perspectives.International journal of molecular sciences · 2026Review
- Technical Neurosurgical Aspects of Pediatric Epilepsy Surgery Including Resections and Disconnections.Pediatric neurosurgery · 2026Review
- Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.Communications medicine · 2025Article
- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
- Vestibular-Dependent Functions Following MRgLITT-A Single-Group Longitudinal Study.Brain sciences · 2025Article
- Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.Frontiers in neurology · 2025Article
- Laser interstitial thermal therapy in the management of bottom-of-sulcus dysplasia-related epilepsy.Annals of clinical and translational neurology · 2025Article
- Preclinical evaluation of transaxial intraputaminal trajectory for enhanced distribution of grafted cells in Parkinson's disease.Journal of neurosurgery · 2024Article
- Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 14 institutions in 1 country.
Funding
Abstract
objectiveLaser interstitial thermal therapy (LITT) for mesial temporal lobe epilepsy (mTLE) has reported seizure freedom rates between 36% and 78% with at least 1 year of follow-up. Unfortunately, the lack of robust methods capable of incorporating the inherent variability of patient anatomy, the variability of the ablated volumes, and clinical outcomes have limited three-dimensional quantitative analysis of surgical targeting and its impact on seizure outcomes. We therefore aimed to leverage a novel image-based methodology for normalizing surgical therapies across a large multicenter cohort to quantify the effects of surgical targeting on seizure outcomes in LITT for mTLE.
methodsThis multicenter, retrospective cohort study included 234 patients from 11 centers who underwent LITT for mTLE. To investigate therapy location, all ablation cavities were manually traced on postoperative magnetic resonance imaging (MRI), which were subsequently nonlinearly normalized to a common atlas space. The association of clinical variables and ablation location to seizure outcome was calculated using multivariate regression and Bayesian models, respectively.
resultsAblations including more anterior, medial, and inferior temporal lobe structures, which involved greater amygdalar volume, were more likely to be associated with Engel class I outcomes. At both 1 and 2 years after LITT, 58.0% achieved Engel I outcomes. A history of bilateral tonic-clonic seizures decreased chances of Engel I outcome. Radiographic hippocampal sclerosis was not associated with seizure outcome. SIGNIFICANCE: LITT is a viable treatment for mTLE in patients who have been properly evaluated at a comprehensive epilepsy center. Consideration of surgical factors is imperative to the complete assessment of LITT. Based on our model, ablations must prioritize the amygdala and also include the hippocampal head, parahippocampal gyrus, and rhinal cortices to maximize chances of seizure freedom. Extending the ablation posteriorly has diminishing returns. Further work is necessary to refine this analysis and define the minimal zone of ablation necessary for seizure control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.