Evidence map›Paper›PMID 31112015›Full record

SynthesisObesity (Silver Spring, Md.)2019

Adipose Tissue Protein Glycoxidation is Associated with Weight-Loss Potential.

José C E Serrano, Juan Antonio Baena-Fustegueras, Meritxell Martin-Gari, Helene Rassendren, Anna Cassanye, Alba Naudí, Carolina López-Cano, Enric Sánchez, María Cruz de la Fuente-Juárez, Fernando Herrerías González and 3 more

Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06226194 (Genetic Susceptibility to Predict Weight Loss After Bariatric Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06226194 recruitingnot on this mapstarted 2024, after this paper: background citation

Genetic Susceptibility to Predict Weight Loss After Bariatric Surgery

Typeobservational_patient_registrySponsorInstitut de Recerca Biomèdica de LleidaRan2024 to 2028Enrolled6,966ConditionsBariatric Surgery Candidate, Obesity, Morbid, Genetic Predisposition, Metabolic Syndrome
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

José C E SerranoDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.ORCID 0000-0001-6714-6061
Juan Antonio Baena-FusteguerasGeneral and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
Meritxell Martin-GariDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.
Helene RassendrenDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.
Anna CassanyeDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.
Alba NaudíDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.
Carolina López-CanoEndocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
Enric SánchezEndocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
María Cruz de la Fuente-JuárezGeneral and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
Fernando Herrerías GonzálezGeneral and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
Jorge J Olsina KisslerGeneral and Digestive Surgery Service, Endocrine, Bariatric and Metabolic Surgery Unit, Arnau de Vilanova University Hospital, Lleida, Spain.
Albert LecubeEndocrinology and Nutrition Department, Arnau de Vilanova University Hospital; and Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, Lleida, Spain.
Manuel Portero-OtínDepartment of Experimental Medicine, University of Lleida, Lleida, Spain.
Universitat de Lleida · ESHospital Universitari Arnau de Vilanova · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to characterize the differences in protein oxidation biomarkers in adipose tissue (AT) as an indicator of AT metabolism and bariatric surgery weight-loss success.

methodsA human model, in which sixty-five individuals with obesity underwent bariatric surgery, and a diet-induced obesity animal model, in which animals were treated for 2 months with normocaloric diets, were analyzed to determine the associations between AT protein oxidation and body weight loss. Protein oxidative biomarkers were determined by gas chromatography/mass spectrometry in AT from human volunteers before the surgery, as well as 2 months after a diet treatment in the animal model.

resultsThe levels of carboxyethyl-lysine (CEL) and 2-succinocystein (2SC) in both visceral and subcutaneous AT before the surgery directly correlated with greater weight loss in both human and animal models. 2SC levels in subcutaneous AT greater than 4.7 × 10

conclusionsCEL and 2SC in AT are useful biomarkers of AT metabolism and predict the individual's ability to reduce body weight after bariatric surgery.

Indexed as

Adipose TissueAdultAgedAnimalsBariatric SurgeryBiomarkersDisease Models, AnimalFemaleGlycosylationHumansMaleMiceMiddle AgedObesityOxidation-ReductionProteinsBiomarkersProteins

Identifiers

PMID31112015
PMCPMC6618070
OpenAlexW2945285722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.