ArticleMilitary medicine2019
Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Pain Following Amputation.
Article in Military medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05046639 (Sciatic Block in Contralateral Limb for Treatment of Refractory Phantom and Residual Limb Pain; a Triple-Blind Randomized Crossover Controlled Trial), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sciatic Block in Contralateral Limb for Treatment of Refractory Phantom and Residual Limb Pain; a Triple-Blind Randomized Crossover Controlled Trial
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Peripheral Nerve Stimulation Is Effective in the Management of Trigeminal Pain: A Systematic Review and meta-analysis.Current pain and headache reports · 2026Pooled it
- Beyond traditional therapies: a network meta-analysis on the treatment efficacy for chronic phantom limb pain.Regional anesthesia and pain medicine · 2025Pooled it
- Peripheral Nerve Stimulation in Pain Management: A Systematic Review.Pain physician · 2021Pooled it
- Primary 3-Month Outcomes of a Double-Blind Randomized Prospective Study (The QUEST Study) Assessing Effectiveness and Safety of Novel High-Frequency Electric Nerve Block System for Treatment of Post-Amputation Pain.Journal of pain research · 2024Trial
- Effective Interventions in Restoring Mobility and Relieving Pain After Lower Limb Amputation.Journal of orthopaedics and sports medicine · 2026Article
- Pain intensity and opioid consumption after temporary and permanent peripheral nerve stimulation: a 2-year multicenter analysis.Regional anesthesia and pain medicine · 2025Article
- Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine.The Korean journal of pain · 2025Review
- Targeted Interventional Therapies for the Management of Postamputation Pain: A Comprehensive Review.Biomedicines · 2025Review
- Patient-Reported Outcomes with Peripheral Nerve Stimulation for Low Back Pain from Vertebral Plana Deformities: A Case Series.Journal of clinical medicine · 2025Article
- Consensus Guidelines from the American Society of Pain and Neuroscience for the Use of 60-Day Peripheral Nerve Stimulation Therapy. A NEURON Living Guideline Project.Journal of pain research · 2025Article
- Consensus Guidelines for the Use of Peripheral Nerve Stimulation in the Treatment of Chronic Pain and Neurological Diseases: A Neuron Project from the American Society of Pain and Neuroscience.Journal of pain research · 2025Article
- Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review.Pain and therapy · 2024Review
- Multiphysics analysis of the dual role of magnetoelectric nanoparticles in a microvascular environment: from magnetic targeting to electrical activation.Frontiers in bioengineering and biotechnology · 2024Article
- A Review of Chronic Pain and Device Interventions: Benefits and Future Directions.Pain and therapy · 2023Review
- Mechanism of Action of Peripheral Nerve Stimulation for Chronic Pain: A Narrative Review.International journal of molecular sciences · 2023Review
- Importance of Breast Sensation After Mastectomy: Evidence from Three Sources.Women's health reports (New Rochelle, N.Y.) · 2023Article
- Peripheral Nerve Stimulation for the Treatment of Phantom Limb Pain: A Case Series.Case reports in anesthesiology · 2023Article
- Peripheral Nerve Stimulation in Painful Conditions of the Upper Extremity-An Overview.Biomedicines · 2022Review
- Peripheral Nerve Stimulation for Lower Extremity Pain.Biomedicines · 2022Review
- Cancer Pain Management-New Therapies.Current oncology reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
introductionChronic pain and reduced function are significant problems for Military Service members and Veterans following amputation. Peripheral nerve stimulation (PNS) is a promising therapy, but PNS systems have traditionally been limited by invasiveness and complications. Recently, a novel percutaneous PNS system was developed to reduce the risk of complications and enable delivery of stimulation without surgery. MATERIALS AND
methodsPercutaneous PNS was evaluated to determine if stimulation provides relief from residual and phantom limb pain following lower-extremity amputation. PNS leads were implanted percutaneously to deliver stimulation to the femoral and/or sciatic nerves. Patients received stimulation for up to 60 days followed by withdrawal of the leads.
resultsA review of recent studies and clinical reports found that a majority of patients (18/24, 75%) reported substantial (≥50%) clinically relevant relief of chronic post-amputation pain following up to 60 days of percutaneous PNS. Reductions in pain were frequently associated with reductions in disability and pain interference.
conclusionsPercutaneous PNS can durably reduce pain, thereby enabling improvements in quality of life, function, and rehabilitation in individuals with residual or phantom limb pain following amputation. Percutaneous PNS may have additional benefit for Military Service members and Veterans with post-surgical or post-traumatic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.