ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
The Predictive Performance of a Pneumonia Severity Score in Human Immunodeficiency Virus-negative Children Presenting to Hospital in 7 Low- and Middle-income Countries.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review.Journal of global health · 2023Pooled it
- Prevalence of hypoxaemia in children with pneumonia in low-income and middle-income countries: a systematic review and meta-analysis.The Lancet. Global health · 2022Pooled it
- Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review.BMJ open · 2020Pooled it
- Identifying modifiable risk factors for mortality in children aged 1-59 months admitted with WHO-defined severe pneumonia: a single-centre observational cohort study from rural Malawi.BMJ paediatrics open · 2022Trial
- Early Clinical and Inflammatory Predictors of Supplemental Oxygen Requirement in Children Hospitalized with Acute Lower Respiratory Infection: A Multivariable Analysis.Microorganisms · 2026Article
- Risk factors associated with disease severity among children hospitalised with community-acquired pneumonia in Angola.Journal of global health · 2026Observational
- External Validation of Pediatric Pneumonia and Bronchiolitis Risk Scores to Predict Mortality in Children Hospitalized in Kenya: A Retrospective Cohort Study.The Journal of infectious diseases · 2026Article
- Development and validation of a machine learning model for critical progression risk in pediatric severe community-acquired pneumonia.Scientific reports · 2025Article
- Online Tool for Predicting Severe Cases of Childhood Community-Acquired Pneumonia Based on the PIRO Concept.Pediatric pulmonology · 2025Article
- Development and Internal Validation of a Risk Assessment Tool to Identify Neonates at Risk for 60-Day Hospital Readmission in Dar es Salaam, Tanzania, and Monrovia, Liberia.The American journal of tropical medicine and hygiene · 2025Observational
- Narrative review of clinical prediction models for paediatric community acquired pneumonia.Paediatric respiratory reviews · 2025Review
- Advancing severity grading for risk-differentiated paediatric pneumonia care.The Lancet. Child & adolescent health · 2025Article
- Paediatric healthcare in Manhiça district through a gender lens: a retrospective analysis of 17 years of morbidity and demographic surveillance data.Journal of global health · 2025Article
- Prediction of inpatient mortality in hospitalised children in low- and middle-income countries: An external validation of paediatric mortality risk scores.Journal of global health · 2024Article
- An Overview of Pediatric Pulmonary Complications During COVID-19 Pandemic: A Lesson for Future.Immunity, inflammation and disease · 2024Review
- Pulse Oximetry Accuracy in Children with Dark Skin Tones: Relevance to Acute Lower Respiratory Infection Care in Low- and Middle-Income Countries.The American journal of tropical medicine and hygiene · 2024Review
- Derivation and Internal Validation of a Novel Risk Assessment Tool to Identify Infants and Young Children at Risk for Post-Discharge Mortality in Dar es Salaam, Tanzania and Monrovia, Liberia.The Journal of pediatrics · 2024Observational
- Observational
- Clinical algorithm reduces antibiotic use among children presenting with respiratory symptoms to hospital in central Vietnam.Pneumonia (Nathan Qld.) · 2023Article
- In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Article
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Authors and funding
29 authors at 13 institutions in 11 countries.
Funding
Abstract
backgroundIn 2015, pneumonia remained the leading cause of mortality in children aged 1-59 months.
methodsData from 1802 human immunodeficiency virus (HIV)-negative children aged 1-59 months enrolled in the Pneumonia Etiology Research for Child Health (PERCH) study with severe or very severe pneumonia during 2011-2014 were used to build a parsimonious multivariable model predicting mortality using backwards stepwise logistic regression. The PERCH severity score, derived from model coefficients, was validated on a second, temporally discrete dataset of a further 1819 cases and compared to other available scores using the C statistic.
resultsPredictors of mortality, across 7 low- and middle-income countries, were age <1 year, female sex, ≥3 days of illness prior to presentation to hospital, low weight for height, unresponsiveness, deep breathing, hypoxemia, grunting, and the absence of cough. The model discriminated well between those who died and those who survived (C statistic = 0.84), but the predictive capacity of the PERCH 5-stratum score derived from the coefficients was moderate (C statistic = 0.76). The performance of the Respiratory Index of Severity in Children score was similar (C statistic = 0.76). The number of World Health Organization (WHO) danger signs demonstrated the highest discrimination (C statistic = 0.82; 1.5% died if no danger signs, 10% if 1 danger sign, and 33% if ≥2 danger signs).
conclusionsThe PERCH severity score could be used to interpret geographic variations in pneumonia mortality and etiology. The number of WHO danger signs on presentation to hospital could be the most useful of the currently available tools to aid clinical management of pneumonia.
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