ArticleJournal of biomedical optics2019
Intraoperative photoacoustic screening of breast cancer: a new perspective on malignancy visualization and surgical guidance.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toward noninvasive precision: a meta-analysis of photoacoustic spectroscopy in breast cancer.Lasers in medical science · 2025Pooled it
- Investigation of feasibility and diagnostic capability of ultrasound-guided photoacoustic tomography for breast surgical margins.Npj imaging · 2026Article
- Label-free streamlined photoacoustic image guidance facilitates NIR-II photoablation in models of melanoma lung metastases.The Journal of clinical investigation · 2026Article
- Full-view volumetric photoacoustic imaging using a hemispheric transducer array combined with an acoustic reflector.Biomedical optics express · 2024Article
- Investigating the feasibility of a hand-held photoacoustic imaging probe for margin assessment during breast conserving surgery.Photoacoustics · 2022Article
- Approaching closed spherical, full-view detection for photoacoustic tomography.Journal of biomedical optics · 2022Article
- Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment.Journal of biomedical optics · 2021Review
- Photoacoustic-guided surgery from head to toe [Invited].Biomedical optics express · 2021Review
- Recent advances toward clinical applications of photoacoustic microscopy: a review.Science China. Life sciences · 2020Review
- Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Lipid-weighted intraoperative photoacoustic tomography of breast tumors: Volumetric comparison to preoperative MRI.Photoacoustics · 2020Article
- Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies.Translational oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
High re-excision rates in breast-conserving surgery call for a new intraoperative approach to the lumpectomy margin evaluation problem. The unique intraoperative imaging system, presented here, demonstrated the capability of photoacoustic tomography (PAT) to deliver optical sensitivity and specificity, along with over 2-cm imaging depth, in a clinical setting. The system enabled the evaluation of tumor extent, shape, morphology, and position within lumpectomy specimens measuring up to 11 cm in diameter. The investigation included all major breast cancer-related lesions, such as invasive ductal carcinoma (IDC), multifocal IDC, ductal carcinoma in situ and combinations of these variants. Coregistration with established ultrasound (US) technology, as well as comparison to specimen radiography, validated the performance of PAT, which appeared to facilitate better tumor visualization. Contrary to expected PA contrast mechanisms, PAT images of hemoglobin distribution correlated poorly with US-determined tumor location, while hypointense regions in lipid-weighted PAT images were in better agreement with US.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.