Evidence map›Paper›PMID 31111449›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

A new method to recommend left ventricular lead positions for improved CRT volumetric response and long-term prognosis.

Xinwei Zhang, Zhiyong Qian, Haipeng Tang, Wei Hua, Yangang Su, Geng Xu, Xingbin Liu, Xiaolin Xue, Jie Fan, Lin Cai and 6 more

Abstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Heart failure in China: epidemiology and current management.Journal of geriatric cardiology : JGC · 2024
    Article
  3. Article
  4. A method using deep learning to discover new predictors from left-ventricular mechanical dyssynchrony for CRT response.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  5. Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  6. Article
  7. Article
  8. Gated SPECT MPI and CT venography fusion: A new approach for appropriate CRT-pacemaker lead placement?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  9. Article
  10. Prognostic value of integrative analysis of electrical and mechanical dyssynchrony in patients with acute heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Xinwei ZhangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu, China.
Zhiyong QianDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu, China.
Haipeng TangSchool of Computing, University of Southern Mississippi, 730 Beach Blvd E, Long Beach, MS, 39560, USA.
Wei HuaArrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Yangang SuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Geng XuDepartment of Cardiology, Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Xingbin LiuDepartment of Cardiology, Westeastern Hospital, Sichuan University, Chengdu, China.
Xiaolin XueDepartment of Cardiology, Affiliated Hospital, Xian Jiaotong University, Xi'an, China.
Jie FanDepartment of Cardiology, Yunnan Province Hospital, Kunming, China.
Lin CaiDepartment of Cardiology, Chengdu Third Hospital, Chengdu, China.
Li ZhuDepartment of Cardiology, Taizhou People's Hospital, Taizhou, People's Republic of China.
Yao WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu, China.
Xiaofeng HouDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu, China.
Ernest V GarciaDepartment of Radiology, Emory University School of Medicine, Atlanta, GA, USA.
Weihua ZhouSchool of Computing, University of Southern Mississippi, 730 Beach Blvd E, Long Beach, MS, 39560, USA. weihua.zhou@usm.edu.
Jiangang ZouDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu, China. jgzou@njmu.edu.cn.

Funding

American Heart Association-American Stroke Association 17AIREA33700016
6 · The paper itself

Abstract

objectivesUsing ECG-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), we sought to develop and validate a new method to recommend left ventricular (LV) lead positions in order to improve volumetric response and long-term prognosis after cardiac resynchronization therapy (CRT).

methodsSeventy-nine patients received gated SPECT MPI at baseline, and echocardiography at baseline and follow-up. The volumetric response referred to a reduction of ≥ 15% in LV end-systolic volume 6 months after CRT. After excluding apical, septal, and scarred segments, there were three levels of recommended segments: (1) the optimal recommendation: the latest contracting viable segment; (2) the 2nd recommendation: the late contracting viable segments whose contraction delays were within 10° of the optimal recommendation; and (3) the 3rd recommendation: the viable segments adjacent to the optimal recommendation when there was no late contracting viable segment.

resultsAfter excluding 11 patients whose LV lead was placed in apical or scarred segments, 75.6% of the patients concordant to recommended LV segments (n = 41) responded to CRT while 51.9% of those with non-recommended LV lead locations (n = 27) were responders (P = .043). Response rates were 76.9%, 76.9% , and 73.3% (P = .967), respectively, when LV lead was implanted in the optimal recommendation (n = 13), the 2nd recommendation (n = 13), and the 3rd recommendation (n = 15). LV leads placed at recommended segments reduced composite events of all-cause mortality or heart failure (HF) rehospitalization compared with pacing at non-recommended segments (log-rank χ

conclusionsPacing in the recommended LV lead segments identified on gated SPECT MPI was associated with improved volumetric response to CRT and long-term prognosis.

Indexed as

AdultAgedCardiac Resynchronization TherapyFemaleHeart VentriclesHumansMaleMiddle AgedMyocardial Perfusion ImagingPrognosisTomography, Emission-Computed, Single-PhotonCardiac resynchronization therapyheart failureleft ventricular lead positionmyocardial perfusion imagingSPECT

Identifiers

PMID31111449
PMCPMC10959571

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.