Evidence map›Paper›PMID 31111413›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Structures and Relative Glycosidic Bond Stabilities of Protonated 2'-Fluoro-Substituted Purine Nucleosides.

Zachary J Devereaux, C C He, Y Zhu, H A Roy, N A Cunningham, L A Hamlow, G Berden, J Oomens, M T Rodgers

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Zachary J DevereauxDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
C C HeDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Y ZhuDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
H A RoyDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
N A CunninghamDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
L A HamlowDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
G BerdenInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, Toernooiveld 7c, 6525 ED, Nijmegen, The Netherlands.
J OomensInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, Toernooiveld 7c, 6525 ED, Nijmegen, The Netherlands.
M T RodgersDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA. mrodgers@chem.wayne.edu.ORCID http://orcid.org/0000-0002-5614-0948
Wayne State University · USRadboud University Nijmegen · NL

Funding

Division of Biological Infrastructure DBI-0922819Division of Chemistry CHE-1709789Office of International Science and Engineering OISE-1357887
6 · The paper itself

Abstract

The 2'-substituent is the primary distinguishing feature between DNA and RNA nucleosides. Modifications to this critical position, both naturally occurring and synthetic, can produce biologically valuable nucleoside analogues. The unique properties of fluorine make it particularly interesting and medically useful as a synthetic nucleoside modification. In this work, the effects of 2'-fluoro modification on the protonated gas-phase purine nucleosides are examined using complementary tandem mass spectrometry and computational methods. Direct comparisons are made with previous studies on related nucleosides. Infrared multiple photon dissociation action spectroscopy performed in both the fingerprint and hydrogen-stretching regions allows for the determination of the experimentally populated conformations. The populated conformers of protonated 2'-fluoro-2'-deoxyadenosine, [Adofl+H]

Indexed as

DeoxyadenosinesDideoxynucleosidesHalogenationHydrogen BondingModels, MolecularMolecular ConformationProtonsPurine NucleosidesSpectrophotometry, Infrared2'-fluoro-2',3'-dideoxyguanosine2'-fluoro-2'-deoxyadenosineDeoxyadenosinesDideoxynucleosidesProtonsPurine NucleosidesElectronic structure theoryEnergy-resolved collision-induced dissociation (ER-CID)Fluorinated nucleoside analoguesFluorine hydrogen bondFree electron laser (FEL)Infrared multiple photon dissociation (IRMPD) action spectroscopyModified purine nucleosidesSurvival yield analysis

Identifiers

PMID31111413
OpenAlexW2946643768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.