SynthesisBehavior genetics2019
Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.
Synthesis in Behavior genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Nature human behaviour · 2024Pooled it
- Pooled it
- Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data.Social science & medicine (1982) · 2022Pooled it
- Differential Relations of Parental Behavior to Children's Early Executive Function as a Function of Child Genotype: A Systematic Review.Clinical child and family psychology review · 2022Pooled it
- Synergistic Effects of Early Psychosocial Factors and Polygenic Risk for Smoking: a Cross-Sectional Analysis of a Sample of Older Adults in the United States.Developmental psychobiology · 2026Article
- Ethnic Discrimination Moderates Genetic Influences on Adolescent Internalizing and Externalizing Psychopathology.Behavior genetics · 2026Article
- Breaking the intergenerational cycle of extinction of experience: Actions needed and pathways forward.Cambridge prisms. Extinction · 2026Review
- Interaction between genetic predisposition to successful ageing and chronic air pollution on lung disease in elderly women: results of the German SALIA cohort.BMJ open respiratory research · 2025Article
- Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.Translational psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Social and Environmental Predictors of Youth Alcohol and Cannabis Initiation Risk: The Moderating Role of Family History of Substance Use Disorders.Substance use & misuse · 2025Article
- Risk Factors and Onset of Illicit Drug Use among Filipino Youth: A Cross-sectional Analysis of Sociodemographic and Environmental Influences.Acta medica Philippina · 2025Article
- Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.Science advances · 2024Article
- Interactive effects of genetic liability and combat exposure on risk of alcohol use disorder among US service members.Drug and alcohol dependence · 2024Article
- Good parent-child relationship protects against alcohol use in maltreated adolescent females carrying theFrontiers in psychiatry · 2024Article
- Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Psychological medicine · 2023Observational
- Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.medRxiv : the preprint server for health sciences · 2023Article
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.Translational psychiatry · 2023Article
- The Associations of Adverse Childhood Experiences (ACEs) With Substance Use in Young Adults: A Systematic Review.Substance abuse : research and treatment · 2023Review
- Examining interactions between polygenic scores and interpersonal trauma exposure on alcohol consumption and use disorder in an ancestrally diverse college cohort.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Studies testing the effect of single genetic variants on substance use have had modest success. This paper reviewed 39 studies using polygenic measures to test interaction with any type of environmental exposure (G×E) in alcohol, tobacco, and cannabis use. Studies using haplotype combinations, sum scores of candidate-gene risk alleles, and polygenic scores (PS) were included. Overall study quality was moderate, with lower ratings for the polygenic methods in the haplotype and candidate-gene score studies. Heterogeneity in investigated environmental exposures, genetic factors, and outcomes was substantial. Most studies (N = 30) reported at least one significant G×E interaction, but overall evidence was weak. The majority (N = 26) found results in line with differential susceptibility and diathesis-stress frameworks. Future studies should pay more attention to methodological and statistical rigor, and focus on replication efforts. Additional work is needed before firm conclusions can be drawn about the importance of G×E in the etiology of substance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.