Evidence map›Paper›PMID 31111330›Full record

ArticleJournal of molecular neuroscience : MN2019

Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.

Qian Wang, Jingyun Hu, Yuran Liu, Jingjing Li, Beibei Liu, Mingming Li, Shujie Lou

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. The multifaceted impact of physical exercise on FoxO signaling pathways.Frontiers in cell and developmental biology · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Review
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  16. Article
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  18. Article
  19. Review
  20. FOXO1 regulates NLRP3 inflammasome proteins in LPS-induced cardiotoxicity.American journal of translational research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qian WangKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Jingyun HuKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Yuran LiuKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Jingjing LiKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Beibei LiuKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Mingming LiKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China.
Shujie LouKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, No 399 Changhai Road, Shanghai, China. shujielou319@163.com.ORCID http://orcid.org/0000-0002-3237-2605
Shanghai University of Sport · CNWeifang Medical University · CN

Funding

National Natural Science Foundations of China 81572241Shanghai Key Laboratory of Human Sport Competence Development and Maintenance 11DZ2261100
6 · The paper itself

Abstract

Diabetes mellitus is metabolic syndrome and a risk factor for cognitive dysfunction-related diseases such as dementia, especially Alzheimer's disease (AD), which is associated with chronic inflammation and abnormal insulin signaling pathway. Exercise, a known potential therapy for diabetes, can also alleviate neurodegeneration. We evaluated the effects of aerobic exercise on inflammation and insulin signaling pathway in the prefrontal cortex of diabetic rats. Male SD rats were fed with a normal diet or a high-fat diet (HFD) for 8 weeks. Then, part of the HFD rats was selected for aerobic exercise training. Our results show that aerobic exercise can improve the expression of synaptic plasticity-related proteins and reduce the phosphorylation of Tau by inhibiting the inflammatory signaling pathway and ameliorating the insulin signaling pathway in diabetic rats.

Indexed as

Physical Conditioning, AnimalSignal TransductionAnimalsDiabetes Mellitus, ExperimentalForkhead Box Protein O1InsulinMaleNerve Tissue ProteinsNeuronal PlasticityNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPhosphatidylinositol 3-KinasesPrefrontal CortexProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyForkhead Box Protein O1Foxo1 protein, ratInsulinNerve Tissue ProteinsNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akttau ProteinsAerobic exerciseDiabetesInflammationInsulin signalPrefrontal cortexSynaptic proteins

Identifiers

PMID31111330
OpenAlexW2946092086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.