Evidence map›Paper›PMID 31111311›Full record

ArticleFamilial cancer2019

Endoscopic full thickness resection for early colon cancer in Lynch syndrome.

Alexandra M J Langers, Jurjen J Boonstra, James C H Hardwick, Jolein van der Kraan, Arantza Farina Sarasqueta, Hans F A Vasen

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Familial cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexandra M J LangersDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands. a.m.j.langers@lumc.nl.
Jurjen J BoonstraDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
James C H HardwickDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Jolein van der KraanDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Arantza Farina SarasquetaDepartment of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
Hans F A VasenDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Leiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subtotal colectomy is usually the therapy of choice in Lynch syndrome patients diagnosed with colon cancer. In patients who develop cancer after the age of 50-60 years, segmental colectomy is considered a good alternative. Although the endoscopic treatment of early colorectal cancer in non-Lynch patients has increased in the last decades, almost all patients with a Lynch syndrome-associated colorectal malignancy undergo surgery, even if the tumour is diagnosed in a (very) early stage. One of the endoscopic treatment options for early colorectal cancer is an endoscopic full thickness resection (eFTR). This treatment modality allows optimal pathological examination of the resection specimen, as a transmural resection is performed with optimal T-staging of the tumour. We report a case of a 62 year old man, diagnosed with MSH2-Lynch syndrome, who underwent successful eFTR treatment of an early (pT1) colon cancer located in the ascending colon, with no signs of recurrence 12 months after treatment. We discuss the pros and cons of endoscopic resection of early colorectal carcinoma in Lynch syndrome patients.

Indexed as

AdenocarcinomaCarcinomaColon, AscendingColonic NeoplasmsColonoscopyColorectal Neoplasms, Hereditary NonpolyposisEarly Detection of CancerHumansKidney NeoplasmsMaleMiddle AgedMutS Homolog 2 ProteinPancreatic NeoplasmsMSH2 protein, humanMutS Homolog 2 ProteinColorectal cancereFTREndoscopic resectionFull-thickness resectionLynch syndrome

Identifiers

PMID31111311
PMCPMC6559999
OpenAlexW2945137544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.