ReviewCancer causes & control : CCC2019
Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link.
Review in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between neighborhood socioeconomic status and breast cancer incidence and mortality risk: a large-scale cohort studies systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2025Pooled it
- Neighborhood Deprivation and Rurality Associated With Patient-Reported Outcomes and Survival in Men With Prostate Cancer in NRG Oncology RTOG 0415.International journal of radiation oncology, biology, physics · 2023Trial
- Intersectionality of Race, Rurality on Persistent Poverty Disparities in Cancer Mortality in Alabama.Cancer medicine · 2026Article
- Neighborhood deprivation and oncotype DX recurrence scores among Black and White women: the interplay between race, place, and tumor biology.NPJ breast cancer · 2026Article
- Uptake and Utility of Geographically Sensitive Neighborhoodwide Association Studies of Cancer.JAMA network open · 2026Article
- A Geographically Sensitive Neighborhood Exposome-Wide Association Study for Breast Cancer Survival.JAMA network open · 2026Article
- The role of AI for improved management of breast cancer: Enhanced diagnosis and health disparity mitigation.Computer methods and programs in biomedicine · 2025Review
- Perceived racial discrimination in health care in relation to late stage at breast cancer diagnosis.Breast cancer research : BCR · 2025Article
- Understanding the role of neighborhood deprivation in racial disparities in triple-negative breast cancer.Cancer · 2025Article
- Area deprivation index and breast cancer outcomes among patients in Western New York.Breast cancer research and treatment · 2025Article
- Allostatic load and cancer risk, progression, and mortality in epidemiologic studies.American journal of epidemiology · 2025Article
- Ethnic enclaves, neighborhood socioeconomic status, and obesity among Hispanic women in Chicago: a latent profile analysis approach.Cancer causes & control : CCC · 2025Article
- Neighborhood Disinvestment Predicts Shorter Cancer Survival Time among Black Women Diagnosed with Invasive Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Geospatial Genomics: Operationalizing Multilevel Conceptual Frameworks of Cancer Health Outcomes to Account for Gene-Person-Place Relationships.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Historical redlining and clustering of present-day breast cancer factors.Cancer causes & control : CCC · 2025Article
- Creating a predictive model and online calculator for high-value care outcomes following glioblastoma resection: incorporating neighborhood socioeconomic status index.Journal of neuro-oncology · 2025Observational
- Recurrence Patterns and Long-Term Results After Curative Surgery for Patients With Breast Cancer.Annals of surgical oncology · 2025Article
- Neighborhood socioeconomic deprivation and patient-reported outcomes in symptom management trials for women with breast cancer.Breast cancer research and treatment · 2025Article
- Impact of Structural Racism and Social Determinants of Health on Disparities in Breast Cancer Mortality.Cancer research · 2024Review
- Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Neighborhoods encompass complex environments comprised of unique economic, physical, and social characteristics that have a profound impact on the residing individual's health and, collectively, on the community's wellbeing. Neighborhood disadvantage (ND) is one of several factors that prominently contributes to racial breast cancer (BC) health disparities in American women. African American (AA) women develop more aggressive breast cancer features, such as triple-negative receptor status and more advanced histologic grade and tumor stage, and suffer worse clinical outcomes than European American (EA) women. While the adverse effects of neighborhood disadvantage on health, including increased risk of cancer and decreased longevity, have recently come into focus, the specific molecular mechanisms by which neighborhood disadvantage increases BC risk and worsens BC outcomes (survivorship, recurrence, mortality) are not fully elucidated. This review illuminates the probable biological links between neighborhood disadvantage and predominantly BC risk, with an emphasis on stress reactivity and inflammation, epigenetics and telomere length in response to adverse neighborhood conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.