Evidence map›Paper›PMID 31111118›Full record

ArticleCurrent developments in nutrition2019

Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands.

Adriana V Gaitán, JodiAnne T Wood, Noel W Solomons, Juliana A Donohue, Lipin Ji, Yingpeng Liu, Spyros P Nikas, Fan Zhang, Lindsay H Allen, Alexandros Makriyannis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  5. Metabolomics can provide new insights into perinatal nutrition.Acta paediatrica (Oslo, Norway : 1992) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Adriana V GaitánLouisiana State University, Baton Rouge, LA.ORCID 0000-0003-4401-6568
JodiAnne T WoodCenter for Drug Discovery, Northeastern University, Boston, MA.
Noel W SolomonsCenter for Studies of Sensory Impairment, Aging and Metabolism, Guatemala.
Juliana A DonohueUS Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center; University of California, Davis, CA.ORCID 0000-0002-1013-2280
Lipin JiCenter for Drug Discovery, Northeastern University, Boston, MA.ORCID 0000-0001-9956-3855
Yingpeng LiuCenter for Drug Discovery, Northeastern University, Boston, MA.
Spyros P NikasCenter for Drug Discovery, Northeastern University, Boston, MA.
Fan ZhangLouisiana State University, Baton Rouge, LA.
Lindsay H AllenUS Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center; University of California, Davis, CA.
Alexandros MakriyannisCenter for Drug Discovery, Northeastern University, Boston, MA.
Carol J Lammi-KeefeLouisiana State University, Baton Rouge, LA.
Northeastern University · USAgricultural Research Service · USLouisiana State University · USPennington Biomedical Research Center · US

Funding

University of California Global Health Institute Program for Fellows and ScholarsR25TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, CRAIG R, STRATHDEE, STEFFANIE A. · 2012 to 2017
$6.4M
FIC NIH HHS R25 TW009343
6 · The paper itself

Abstract

backgroundRecognized as the gold-standard ideal fare, human milk has a unique composition that meets infants' needs throughout development. Endocannabinoids and endocannabinoid-like compounds [endocannabinoid metabolome (ECM)] are endogenous lipid mediators derived from long-chain polyunsaturated fatty acids. Based on animal models, it has been proposed that endocannabinoid arachidonoyl glycerol (AG) plays a role in establishing the suckling response during lactation. In addition, endocannabinoid ethanolamides have been shown to stimulate food intake. The mechanisms of action and the role of the ECM in human milk are not fully understood.

objectivesThe present study aimed to characterize and quantify the ECM in human milk samples from an underserved population in Guatemala.

methodsHuman milk samples were collected from lactating women (

resultsOverall, concentrations in the ethanolamide group were lower than the glycerols. A time effect was observed for ARA, DHA, EPA, and PEA across the 3 time points (

conclusionsOur study identified the ECM in mature human milk and provides the first report for a population with health disparities within a developing country. The few studies available have been conducted in developed countries. Hypotheses for future studies can be developed based on this study's data to help elucidate specific roles for members of the ECM and how this biological system modulates infant health and development.

Indexed as

endocannabinoidshuman milkinfant feedinginfant healthlong-chain polyunsaturated fatty acids

Identifiers

PMID31111118
PMCPMC6517780
OpenAlexW2922885565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.