ArticleInternational journal of cardiology. Heart & vasculature2019
Impact of medical therapy for cardiovascular disease on left ventricular diastolic properties and remodeling.
Article in International journal of cardiology. Heart & vasculature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Medium to Long Term Follow-Up of Treated Hypertensive Mediated Heart Disease.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Observational
- Strategies for management of heart failure with preserved ejection fraction.International journal of cardiology. Heart & vasculature · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular (LV) remodeling and diastolic properties are affected by both underlying cardiovascular disease/cardiovascular disease risk factors (CVDRFs) and corresponding medication therapy. However, these effects may not be apparent in patients with multiple CVDRFs. We evaluated the effect of medication classes on hemodynamics in a patient cohort with normal LV dimensions and systolic function.
methodsIn 38 participants (61 ± 7 years, 64 ± 9% LV ejection fraction) undergoing coronary angiography, LV pressure measurement and cardiac magnetic resonance imaging was performed. The effects of coronary artery disease (CAD), CVDRFs and their corresponding medication therapy on LV parameters were analyzed considering the number of CAD/CVDRFs and 'adequacy' of medication therapy to address each existing condition with specific indication-based medication classes.
resultsOf the patients studied, 68% had CAD, 87% had hypertension, 87% had dyslipidemia, and 45% had diabetes. Neither individual or total number of CAD/CVDRFs were associated with overall differences in LV diastolic parameters. However, those without (n = 20) and with (n = 18) 'adequate' medication therapy for underlying CAD/CVDRFs differed in values of LV end diastolic pressure (17 ± 4 vs. 11 ± 5 mm Hg, P < 0.001), wall stress (3.9 ± 1.6 vs. 2.2 ± 1.2 x1000 N/m
conclusionsOur results suggest an association between the degree of LV diastolic impairment and LV remodeling with the intensity of treatment for CAD/CVDRFs. Comprehensive treatment of all identified CAD/CVDRFs may be an important factor for the preservation of diastolic function.
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