ArticleData in brief2019
Data on the negative regulation of invadopodia activity by MLCK.
Article in Data in brief, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 2 citations in OpenAlex.
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force generation by the head and neck squamous cell carcinoma (HNSCC) cell line SCC-61. We provide data here that this targeted method of MLCK knockdown (KD) resulted in a significant increase in the amount of ECM degradation, number of actively degrading invadopodia, and the number of total invadopodia formed. These data are related to the research article entitled "Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2" Jerrell and Parekh, 2016.
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Registered trials
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