ArticlePediatric gastroenterology, hepatology & nutrition2019
The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
Article in Pediatric gastroenterology, hepatology & nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Comparative Analysis of Breastfeeding and Infant Formulas: Short- and Long-Term Impacts on Infant Nutrition and Health.Food science & nutrition · 2025Review
- An Update of Pharmacological Management in Children with Functional Constipation.Paediatric drugs · 2023Review
- Knowledge and practice of pediatricians regarding childhood constipation in the Arab world: results from a multicenter survey.BMC pediatrics · 2022Article
- Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation.Pediatric gastroenterology, hepatology & nutrition · 2022Review
- Softer More Frequent Stools in Infants With Difficult Stooling Fed Hydrolyzed Protein Formula With Added Prebiotics: Randomized Controlled Trial.Frontiers in pediatrics · 2022Article
- What is the Evidence for Over the Counter Laxatives to Treat Childhood Constipation?Current gastroenterology reports · 2021Review
- An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders.Nutrients · 2021Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the effectiveness of the magnesium (Mg)-enriched formula vs. control formula in constipated infants.
methodsAn open-label, interventional, and the comparator-controlled study was conducted to evaluate the effectiveness of the Mg-enriched formula in formula-fed infants ≤6 months old presenting with functional constipation according to modified Rome IV criteria. Infants were randomized 1:1 to intervention or control formula for 30 days. Parents recorded stool consistency (hard, normal, or watery) and frequency on days 1-7 and 23-29. Physicians recorded patient baseline characteristics and performed the clinical examination at the time of three patient visits (baseline, day 8, and 30).
resultsOf the 286 recruited infants, 143 received the Mg-rich formula and 142 received the control formula. After 7 days, significantly more infants had stools with normal consistency with the Mg-rich formula compared to the infants fed with the control formula (81.8% vs. 41.1%;
conclusionThe Mg-rich formula significantly improved stool consistency and frequency compared to the control formula in constipated infants.
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Registered trials
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