ArticleMalaria research and treatment2019
Association between Inflammatory Cytokine Levels and Thrombocytopenia during
Article in Malaria research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Plasma haem oxygenase-1 and interleukin-6 as adjunct host biomarkers associated with malaria.Frontiers in immunology · 2026Article
- Comparative immunological study of Plasmodium knowlesi infections in humans and macaques: insights into cytokine dynamics.Malaria journal · 2025Article
- Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β.PLoS neglected tropical diseases · 2025Article
- A machine learning approach for early identification of patients with severe imported malaria.Malaria journal · 2024Article
- Mimicking platelet indices in patients with malaria and dengue hemorrhagic fever: characteristics and clinical applications.Tropical medicine and health · 2022Article
- IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria.PLoS neglected tropical diseases · 2022Article
- Occurrence and clinical features of HIV and malaria in co-infected individuals in Osun State, Nigeria.Journal of family medicine and primary care · 2022Article
- Article
- Liver and kidney dysfunction, hypoglycemia, and thrombocytopenia inParasite epidemiology and control · 2021Article
- Role of Platelet Indices as a Potential Marker for Malaria Severity.Journal of parasitology research · 2021Review
- The Interface Between Inflammatory Mediators and MicroRNAs inFrontiers in cellular and infection microbiology · 2021Article
- Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria.Memorias do Instituto Oswaldo Cruz · 2020Article
- Impact of oxidative stress in response to malarial infection during pregnancy: Complications, histological changes, and pregnancy outcomes.Tropical parasitologyArticle
- Thrombocytopenia in malaria patients from an arid region of Western Rajasthan (India).Tropical parasitologyArticle
- Association between inflammatory cytokine levels and anemia duringTropical parasitologyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThrombocytopenia is a most commonly observed complication during malaria infections. Inflammatory cytokines such as IL-1, IL-6, and IL-10 have been documented in malaria induced thrombocytopaenia. This study was aimed to understand the possible relationship between inflammatory cytokines across varying degrees of thrombocytopenia during
methodsA hospital-based cross sectional study was conducted at District Wenlock Hospital in Mangaluru, a city situated along the south-western coastal region of Arabian Sea in India. In this study, blood samples from 627 malaria patients were analyzed for infected parasite species, clinical conditions, platelet levels, and key cytokines that are produced in response to infection; samples from 176 uninfected healthy individuals were used as controls.
resultsThe results of our study showed a high prevalence of malarial thrombocytopenia (platelets <150 ×10
conclusionOverall, the results of our study suggest that inflammatory cytokines influence the transformation of mild forms of thrombocytopenia into severe forms during malarial infections. Further studies are needed to understand the association of inflammatory cytokine responses with severe malaria complications and thrombocytopenia.
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