Evidence map›Paper›PMID 31110366›Full record

ArticleNature microbiology2019

Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis.

Lin Wang, Zhonghua Liu, Jie Wang, Haipeng Liu, Juehui Wu, Tianqi Tang, Haohao Li, Hua Yang, Lianhua Qin, Dapeng Ma and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Cell death pathways in response toInfection and immunity · 2025
    Review
  2. Article
  3. Emerging microbes & infections · 2024
    Article
  4. Article
  5. Article
  6. Type VII secretion system extracellular protein B targets STING to evade host anti-Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. The cause-effect relation of tuberculosis on incidence of diabetes mellitus.Frontiers in cellular and infection microbiology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Virulence-Associated Secretion inFrontiers in immunology · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Rv3722c PromotesFrontiers in cellular and infection microbiology · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 4 institutions in 1 country.

Lin WangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhonghua LiuShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jie WangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Haipeng LiuShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-3338-6291
Juehui WuShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Tianqi TangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Haohao LiShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Hua YangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Lianhua QinShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Dapeng MaShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jianxia ChenShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Feng LiuShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Peng WangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Ruijuan ZhengShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Peng SongDepartment of Microbiology and Immunology, School of Medicine, Tongji University, Shanghai, China.
Yilong ZhouDepartment of Microbiology and Immunology, School of Medicine, Tongji University, Shanghai, China.
Zhenling CuiShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiangyang WuShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaochen HuangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Haijiao LiangShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Shanshan ZhangDepartment of Microbiology and Immunology, School of Medicine, Tongji University, Shanghai, China.
Jingjing CaoDepartment of Microbiology and Immunology, School of Medicine, Tongji University, Shanghai, China.
Chunyan WuDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiping ChenState Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Dan SuState Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Xinchun ChenDepartment of Pathogen Biology, School of Medicine, Shenzhen University, Shenzhen, China.
Gucheng ZengDepartment of Microbiology, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Baoxue GeShanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. baoxue_ge@tongji.edu.cn.ORCID http://orcid.org/0000-0002-4086-8299
Tongji University · CNSichuan University · CNShenzhen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium tuberculosis (Mtb)-derived components are usually recognized by pattern recognition receptors to initiate a cascade of innate immune responses. One striking characteristic of Mtb is their utilization of different type VII secretion systems to secrete numerous proteins across their hydrophobic and highly impermeable cell walls, but whether and how these Mtb-secreted proteins are sensed by host immune system remains largely unknown. Here, we report that MPT53 (Rv2878c), a secreted disulfide-bond-forming-like protein of Mtb, directly interacts with TGF-β-activated kinase 1 (TAK1) and activates TAK1 in a TLR2- or MyD88-independent manner. MPT53 induces disulfide bond formation at C

Indexed as

AnimalsAntigens, BacterialBacterial ProteinsCytokinesFemaleHEK293 CellsHumansImmunity, InnateInflammationLungMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisAntigens, BacterialBacterial ProteinsCytokinesMAP Kinase Kinase Kinase 7MAP Kinase Kinase Kinasesmpt53 protein, Mycobacterium tuberculosisMYD88 protein, humanMyeloid Differentiation Factor 88TLR2 protein, humanToll-Like Receptor 2Transforming Growth Factor betaType VII Secretion Systems

Identifiers

PMID31110366
OpenAlexW2945057372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.