Evidence map›Paper›PMID 31110361›Full record

ArticleNature microbiology2019

Leukotriene B

Erwan Pernet, Jeffrey Downey, Donald C Vinh, William S Powell, Maziar Divangahi

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 55 citations in OpenAlex.

  1. Myeloid cell reprogramming drives enhanced defense againstProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Adipocyte-derived LTB4 programs human NKG2AJournal for immunotherapy of cancer · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Treatment with lipoxin AInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  15. Article
  16. Article
  17. Diverging patterns in innate immunity against respiratory viruses during a lifetime: lessons from the young and the old.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  18. Article
  19. Article
  20. Leukotrienes in Innate Immunity: Still Underappreciated after All These Years?Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erwan PernetDepartment of Medicine, Meakins-Christie Laboratories, McGill International TB Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3595-4755
Jeffrey DowneyDepartment of Medicine, Meakins-Christie Laboratories, McGill International TB Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
Donald C VinhDepartment of Medicine, Meakins-Christie Laboratories, McGill International TB Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
William S PowellDepartment of Medicine, Meakins-Christie Laboratories, McGill International TB Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
Maziar DivangahiDepartment of Medicine, Meakins-Christie Laboratories, McGill International TB Centre, McGill University Health Centre, McGill University, Montreal, Quebec, Canada. maziar.divangahi@mcgill.ca.ORCID http://orcid.org/0000-0002-1254-6110
McGill University Health Centre · CA

Funding

CIHR FDN-143273
6 · The paper itself

Abstract

Host defence against influenza A virus (IAV) infection depends not only on host resistance to eliminate the virus, but also disease tolerance to limit lung tissue damage and maintain pulmonary function. Fatal IAV infections are frequently the result of a maladaptive immune response that compromises disease tolerance rather than host resistance to infection. Here, we show that the leukotriene B

Indexed as

Immune ToleranceAnimalsCell DeathCell LineCell ProliferationHumansImmunity, InnateInfluenza A virusInfluenza, HumanInterferon Type ILeukotriene B4LungMacrophagesMiceMice, Inbred C57BLMice, KnockoutCcr2 protein, mouseInterferon Type ILeukotriene B4Receptor, Interferon alpha-betaReceptors, CCR2Stat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID31110361
OpenAlexW2945979411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.