Evidence map›Paper›PMID 31110349›Full record

ArticleNature medicine2019

End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography.

Diego Ardila, Atilla P Kiraly, Sujeeth Bharadwaj, Bokyung Choi, Joshua J Reicher, Lily Peng, Daniel Tse, Mozziyar Etemadi, Wenxing Ye, Greg Corrado and 2 more

Erratum issued 5 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 5 registered trials, which are not on this map. Cited by 805 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
805citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05432739 recruitingnot on this mapstarted 2021, after this paper: background citation

Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study

TypeobservationalSponsorRoyal Marsden NHS Foundation TrustRan2021 to 2031Enrolled500ConditionsLung Cancer
NCT05876676 recruitingnot on this mapstarted 2023, after this paper: background citation

Rapid Diagnostic Centre Biomarker Study

Typeobservational_patient_registrySponsorRoyal Marsden NHS Foundation TrustRan2023 to 2032Enrolled1,000ConditionsCancer
NCT06565923 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Study on the Staging and Prognosis Model of Bladder Cancer Based on Artificial Intelligence and Multimodal Omics Features

Typeobservational_patient_registrySponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2024 to 2025Enrolled200ConditionsBladder Cancer
NCT06638866 recruitingnot on this mapstarted 2024, after this paper: background citation

Artificial Intelligence-based Health Information Management System and Key Technology Study of Early Screening and Hierarchical Diagnosis and Treatment of Pancreatic Cancer

Typeobservational_patient_registrySponsorChanghai HospitalRan2024 to 2030Enrolled5,000ConditionsPancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Intraepithelial Neoplasias, Intraductal Papillary Mucinous NeoplasmArmsPDAC, Pancreatic precursor lesions
NCT07117045 recruitingnot on this mapstarted 2025, after this paper: background citation

Artificial Intelligence-powered Low-Dose Computed Tomography for Screening of Pancreatic Cancer

TypeobservationalSponsorChanghai HospitalRan2025 to 2032Enrolled400,000ConditionsPancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, High-grade Pancreatic Intraepithelial Neoplasia, PDAC - Pancreatic Ductal AdenocarcinomaArmsDiagnostic Evaluation for Positive AI Findings
3 · Its place in the literature

Who cites it

805 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  16. Tumor metrics imaging core labs: primer for radiologists.Abdominal radiology (New York) · 2026
    Review
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745 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Diego Ardila *Google AI, Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-3458-0037
Atilla P Kiraly *Google AI, Mountain View, CA, USA.
Sujeeth Bharadwaj *Google AI, Mountain View, CA, USA.
Bokyung Choi *Google AI, Mountain View, CA, USA.
Joshua J ReicherStanford Health Care and Palo Alto Veterans Affairs, Palo Alto, CA, USA.
Lily PengGoogle AI, Mountain View, CA, USA.
Daniel TseGoogle AI, Mountain View, CA, USA. tsed@google.com.ORCID http://orcid.org/0000-0001-5315-8539
Mozziyar EtemadiNorthwestern Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6324-9220
Wenxing YeGoogle AI, Mountain View, CA, USA.
Greg CorradoGoogle AI, Mountain View, CA, USA.
David P NaidichNew York University-Langone Medical Center, Center for Biological Imaging, New York City, NY, USA.
Shravya ShettyGoogle AI, Mountain View, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With an estimated 160,000 deaths in 2018, lung cancer is the most common cause of cancer death in the United States

Indexed as

Deep LearningTomography, X-Ray ComputedAlgorithmsDatabases, FactualDiagnosis, Computer-AssistedHumansImaging, Three-DimensionalLung NeoplasmsMass ScreeningNeural Networks, ComputerRetrospective StudiesRisk FactorsUnited States

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.