ArticleScientific reports2019
A quantitative analysis of the contribution of melanopsin to brightness perception.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- The effects of a HEV-filtering contact lens on the brightness of natural images.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Trial
- Overexpression or Activation of Potassium Channel TASK-3 Protects Retinal Ganglion Cells and Restores Visual Function in Optic Nerve Crush.Investigative ophthalmology & visual science · 2026Article
- Article
- Intrinsically photosensitive retinal ganglion cells and visual processing: ipRGCs beyond non-image-forming functions.Frontiers in neuroscience · 2025Review
- What can the eye see with melanopsin?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Illumination by short-wavelength light inside the blind spot decreases light detectability.iScience · 2024Article
- Melanopsin enhances image persistence.Current biology : CB · 2023Article
- Influence of macular pigment on the sensitivity to discomfort glare from daylight.Scientific reports · 2023Article
- Numerical correlation between non-visual metrics and brightness metrics-implications for the evaluation of indoor white lighting systems in the photopic range.Scientific reports · 2023Article
- Brightness perception under photopic conditions: experiments and modeling with contributions of S-cone and ipRGC.Scientific reports · 2023Article
- PySilSub: An open-source Python toolbox for implementing the method of silent substitution in vision and nonvisual photoreception research.Journal of vision · 2023Article
- Aging Effects on Optic Nerve Neurodegeneration.International journal of molecular sciences · 2023Review
- Daylights with high melanopsin stimulation appear reddish in fovea and greenish in periphery.PloS one · 2023Article
- A simple method for comparing peripheral and central color vision by means of two smartphones.Behavior research methods · 2023Article
- A five-primary Maxwellian-view display for independent control of melanopsin, rhodopsin, and three-cone opsins on a fine spatial scale.Journal of vision · 2022Article
- Evaluating the Influence of ipRGCs on Color Discrimination.Journal of imaging · 2022Article
- The role of melanopsin photoreception on visual attention linked pupil responses.The European journal of neuroscience · 2022Article
- Robust visual cortex evoked potentials (VEP) in Gnat1 and Gnat2 knockout mice.Frontiers in cellular neuroscience · 2022Article
- Ratio-based perceptual foundations for rational numbers, and perhaps whole numbers, too?The Behavioral and brain sciences · 2021Article
- Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker.Scientific reports · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the retina, intrinsically photosensitive retinal ganglion cells (ipRGCs) which express photopigment melanopsin have been identified as photoreceptors which differ from cones and rods. It has been established that such melanopsin-expressing RGCs are involved in the circadian photo-entrainment and pupillary light reflexes. An additional projection from ipRGCs to the lateral geniculate nucleus has been identified, which indicates the association of ipRGCs with visual perception induced by the image-forming pathway. Reportedly, ipRGCs modulate brightness perception but quantitative analysis of brightness perception involving melanopsin and cones-based signals has not been elucidated. We conducted brightness perception experiments that involved melanopsin using a novel projector with six primary colors and formulated the results for melanopsin and cone stimuli. The white visual stimuli (5 degrees in size) that we used had a single xy-chromaticity values but melanopsin stimuli were modulated by designing different spectral distributions. Perceived brightness was measured using a magnitude estimation method at several luminance levels in the near periphery (7 degrees). Additionally, pupil diameter was measured for estimating the intensity of visual stimuli on the retina. The results showed that the perceived brightness of a white visual stimulus with different spectral distributions can be described by a summation of the nearly linear melanopsin response and the non-linear cone response with weighted coefficients, and the contribution ratio of melanopsin in brightness perception increased to 50% and more with increasing visual stimulus. These suggest that melanopsin signals play a crucial role in the estimation of the absolute intensity of the light environment by obtaining absolute brightness information even when cones are adapted by light.
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