Evidence map›Paper›PMID 31110244›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Prenatal salivary sex hormone levels and birth-weight-for-gestational age.

Katherine Svensson, Allan C Just, Abby F Fleisch, Alison P Sanders, Marcela Tamayo-Ortiz, Andrea A Baccarelli, Rosalind J Wright, Martha M Téllez-Rojo, Robert O Wright, Heather H Burris

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  4. Testosterone mediates life-history trade-offs in female mammals.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Katherine SvenssonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. katherine.svensson@mssm.edu.
Allan C JustDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abby F FleischCenter for Outcomes Research and Evaluation, Maine Medical Center Research Institute and Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA.
Alison P SandersDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marcela Tamayo-OrtizNational Council of Science and Technology, Mexico City, Mexico.
Andrea A BaccarelliDepartment of Environmental Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Martha M Téllez-RojoNational Institute of Public Health, Cuernavaca, Morelos, Mexico.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Heather H BurrisDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Icahn School of Medicine at Mount Sinai · USInstituto Nacional de Salud Pública · MXColumbia University · USMaine Medical Center Research Institute · USUniversity of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
Organic-metal mixtures and neurodevelopmentR01ES026033 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora, Robert O Wright · 2016 to 2026
$6.1M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) CohortR24ES028522 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton, Maria Jose Rosa · 2017 to 2026
$1.8M
Air Pollution Exposure during Pregnancy, Maternal Glycemia, and OffspringGrowthK23ES024803 · NIEHS · MAINEHEALTH · PI FLEISCH, ABBY · 2015 to 2019
$835k
The Toxic Environment and the Epigenetics of Fetal GrowthK23ES022242 · NIEHS · CHILDREN'S HOSP OF PHILADELPHIA · PI BURRIS, HEATHER HERSON · 2013 to 2017
$790k
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747k
Children's Exposure to Metals, MicroRNAs and Biomarkers of Renal HealthR00ES027508 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANDERS, ALISON P · 2018 to 2020
$738k
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityK99ES023450 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI JUST, ALLAN C. · 2014 to 2015
$163k
NIEHS NIH HHS K23 ES022242NIEHS NIH HHS K23 ES024803NIEHS NIH HHS K99 ES023450NIEHS NIH HHS K99 ES027508NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NIEHS NIH HHS R00 ES027508NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01 ES026033NIEHS NIH HHS R24 ES028522
6 · The paper itself

Abstract

objectiveTo determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age. STUDY

designWe measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status.

resultsIn total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: -0.27 to -0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13-1.99).

conclusionHigher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.

Indexed as

AdultBirth WeightCortisoneDehydroepiandrosteroneEstradiolFemaleFetal MacrosomiaGestational AgeGonadal Steroid HormonesHumansInfant, NewbornInfant, Small for Gestational AgeMaleParityPoisson DistributionPregnancyCortisoneDehydroepiandrosteroneEstradiolGonadal Steroid HormonesProgesteroneTestosterone

Identifiers

PMID31110244
PMCPMC6592744
OpenAlexW2946265509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.