Evidence map›Paper›PMID 31110224›Full record

ArticleScientific reports2019

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease.

Karima Ait-Aissa, Scott C Blaszak, Gisela Beutner, Shirng-Wern Tsaih, Garrett Morgan, Janine H Santos, Michael J Flister, David L Joyce, Amadou K S Camara, David D Gutterman and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Therapeutic Impact of Mitochondrial Transplants for Cardiovascular Diseases.International journal of molecular sciences · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Cardiovascular aging: spotlight on mitochondria.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Karima Ait-AissaCardiovascular Center, Department of Medicine, Med College of Wisconsin, Milwaukee, WI, USA. kaitaissa@mcw.edu.ORCID http://orcid.org/0000-0002-7133-4767
Scott C BlaszakCardiovascular Center, Department of Medicine, Med College of Wisconsin, Milwaukee, WI, USA.
Gisela BeutnerDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Shirng-Wern TsaihDepartment of Physiology, Med College of Wisconsin, Milwaukee, WI, USA.
Garrett MorganDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Janine H SantosGenome Integrity and Structural Biology Laboratory, NIHEHS, Raleigh-Durham, NC, USA.
Michael J FlisterDepartment of Physiology, Med College of Wisconsin, Milwaukee, WI, USA.
David L JoyceDepartment of Surgery, Med College of Wisconsin, Milwaukee, WI, USA.
Amadou K S CamaraDepartment of Physiology, Med College of Wisconsin, Milwaukee, WI, USA.
David D GuttermanCardiovascular Center, Department of Medicine, Med College of Wisconsin, Milwaukee, WI, USA.
Anthony J DonatoDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
George A PorterDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-0726-9988
Andreas M BeyerCardiovascular Center, Department of Medicine, Med College of Wisconsin, Milwaukee, WI, USA. abeyer@mcw.edu.
Medical College of Wisconsin · USUniversity of Rochester Medical Center · USUniversity of Utah · USNational Institute of Environmental Health Sciences · US

Funding

Pivotal Role of Mitochondrial Telomerase in Regulation of Vascular Tone and Redox HomeostasisR01HL133029 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2017 to 2021
$2.2M
Mechanism of Flow-Induced Dilation in the Human MicrocirculationR01HL113612 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2013 to 2016
$1.7M
Differentiation of mitochondrial vs. nuclear function of telomeraseR21OD018306 · OD · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2014 to 2015
$411k
NHLBI NIH HHS R01 HL113612NHLBI NIH HHS R01 HL133029NIH HHS R21 OD018306
6 · The paper itself

Abstract

Coronary artery disease (CAD) is a leading cause of death worldwide and frequently associated with mitochondrial dysfunction. Detailed understanding of abnormalities in mitochondrial function that occur in patients with CAD is lacking. We evaluated mitochondrial damage, energy production, and mitochondrial complex activity in human non-CAD and CAD hearts. Fresh and frozen human heart tissue was used. Cell lysate or mitochondria were isolated using standard techniques. Mitochondrial DNA (

Indexed as

Adenosine TriphosphateCoronary Artery DiseaseDNA, MitochondrialEnergy MetabolismFemaleGlycolysisHeartHumansMaleMiddle AgedMitochondriaNADOxidation-ReductionOxidative PhosphorylationAdenosine TriphosphateDNA, MitochondrialNAD

Identifiers

PMID31110224
PMCPMC6527853
OpenAlexW2946388102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.