Evidence map›Paper›PMID 31110187›Full record

ArticleScientific reports2019

Multiplexed temporally focused light shaping through a gradient index lens for precise in-depth optogenetic photostimulation.

Nicolò Accanto, I-Wen Chen, Emiliano Ronzitti, Clément Molinier, Christophe Tourain, Eirini Papagiakoumou, Valentina Emiliani

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Optogenetics for light control of biological systems.Nature reviews. Methods primers · 2022
    Article
  9. Article
  10. Article
  11. Red Light Optogenetics in Neuroscience.Frontiers in cellular neuroscience · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicolò AccantoWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.
I-Wen ChenWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.ORCID http://orcid.org/0000-0003-0598-7230
Emiliano RonzittiWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.
Clément MolinierWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.
Christophe TourainWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.
Eirini PapagiakoumouWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France.ORCID http://orcid.org/0000-0002-7333-8796
Valentina EmilianiWavefront-Engineering Microscopy group, Neurophotonics Laboratory, CNRS UMR8250, Paris Descartes University, 45 rue des Saints-Pères, 75270, Paris 06, Cedex, France. valentina.emiliani@inserm.fr.

Funding

High speed, high precision volumetric multiphoton neural controlUF1NS107574 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADESNIK, HILLEL · 2018 to 2018
$5.1M
NINDS NIH HHS UF1 NS107574
6 · The paper itself

Abstract

In the past 10 years, the use of light has become irreplaceable for the optogenetic study and control of neurons and neural circuits. Optical techniques are however limited by scattering and can only see through a depth of few hundreds µm in living tissues. GRIN lens based micro-endoscopes represent a powerful solution to reach deeper regions. In this work we demonstrate that cutting edge optical methods for the precise photostimulation of multiple neurons in three dimensions can be performed through a GRIN lens. By spatio-temporally shaping a laser beam in the two-photon regime we project several tens of spatially confined targets in a volume of at least 100 × 150 × 300 µm

Indexed as

AnimalsBrainFemaleLens, CrystallineLensesMaleMiceNeuronsOptogeneticsPhotons

Identifiers

PMID31110187
PMCPMC6527563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.