Evidence map›Paper›PMID 31110175›Full record

ArticleNature communications2019

Local membrane charge regulates β

M J Strohman, S Maeda, D Hilger, M Masureel, Y Du, B K Kobilka

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. pH-Driven βACS omega · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. A biased allosteric modulator functions as a molecular glue to induce βbioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Protective effects of GαNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  16. Article
  17. Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location.bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M J StrohmanDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-6264-7449
S MaedaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-7762-9793
D HilgerDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-5179-1357
M MasureelDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4059-6166
Y DuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA.
B K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Beckman Center Room B157, 279 Campus Drive, Stanford, CA, 94305, USA. kobilka@stanford.edu.
Stanford University · US

Funding

Structure and dynamics of G protein coupled receptor-G protein complexesR01GM083118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOBILKA, BRIAN K, SKINIOTIS, GEORGIOS · 2008 to 2023
$8.3M
THE MECHANISM OF BETA2 ADRENOCEPTOR ACTIVATIONR01NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 1990 to 2021
$6.7M
NIGMS NIH HHS R01 GM083118NINDS NIH HHS R01 NS028471U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM083118U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS028471
6 · The paper itself

Abstract

The β

Indexed as

Amino Acid MotifsAnimalsCationsCell MembraneGTP-Binding Protein alpha Subunits, Gi-GoMembrane LipidsMyocytes, CardiacPhospholipidsReceptors, Adrenergic, beta-2Recombinant ProteinsSf9 CellsSpodopteraStatic ElectricityCationsGTP-Binding Protein alpha Subunits, Gi-GoMembrane LipidsPhospholipidsReceptors, Adrenergic, beta-2Recombinant Proteins

Identifiers

PMID31110175
PMCPMC6527575
OpenAlexW2946259785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.