Evidence map›Paper›PMID 31110169›Full record

ArticleThe American journal of case reports2019

Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk.

Alexandra Siqueira Mello, Ana Paula A Pascalicchio Bertozzi, Maria Manoela D Rodrigues, Rosa Estela Gazeta, Antônio F Moron, Antoni Soriano-Arandes, Stéphanno Gomes Pereira Sarmento, Danila Vedovello, Andrea Cristina B Silva, Thamirys C Grillo Fajardo and 2 more

Abstract readCase Reports
In one paragraph

Article in The American journal of case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023
    Review
  4. Zika virus infection histories in brain development.Disease models & mechanisms · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra Siqueira MelloLaboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Ana Paula A Pascalicchio BertozziDepartment of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Maria Manoela D RodriguesDepartment of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Rosa Estela GazetaDepartment of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Antônio F MoronDepartment of Obstetrics, Federal University of São Paulo (UNIFESP) - Paulista School of Medicine and Paulista Center for Fetal Medicine, São Paulo, SP, Brazil.
Antoni Soriano-ArandesPaediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Stéphanno Gomes Pereira SarmentoDepartment of Obstetrics, Federal University of São Paulo (UNIFESP) - Paulista School of Medicine and Paulista Center for Fetal Medicine, São Paulo, SP, Brazil.
Danila VedovelloLaboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Andrea Cristina B SilvaLaboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Thamirys C Grillo FajardoLaboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.
Steven S WitkinDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York City, NY, USA.
Saulo D PassosDepartment of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates. However, other sources of transmission have been identified since the emergence of this virus in the world population, such as vertical transmission by semen and possibly other body fluids such as vaginal secretion and breast milk. CASE REPORT An infant, born to a mother whose previous delivery was a baby with severe microcephaly, was normal and was negative for Zika virus at birth but developed secondary microcephaly 1 month later, that persisted. The baby was exclusively breast-fed and Zika virus was present in the mother's milk. CONCLUSIONS We report the detection of Zika virus exclusively in the breast milk of a woman after her second delivery of an infant, who later developed microcephaly. This case is consistent with possible vertical transmission.

Indexed as

Breast FeedingInfectious Disease Transmission, VerticalMilk, HumanFemaleHumansInfant, NewbornMicrocephalyZika Virus Infection

Identifiers

PMID31110169
PMCPMC6543951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.