Evidence map›Paper›PMID 31110102›Full record

ArticleBMJ open2019

Health-related quality of life and well-being in people over 75 years of age with end-stage kidney disease managed with dialysis or comprehensive conservative care: a cross-sectional study in the UK and Australia.

Karan K Shah, Fliss E M Murtagh, Kevin McGeechan, Su Crail, Aine Burns, Anh D Tran, Rachael L Morton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Patient-reported outcome measures for life participation in peritoneal dialysis: a systematic review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Pooled it
  5. Trial
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  7. Review
  8. Article
  9. Review
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Shared decision making in elderly patients with kidney failure.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. [Peritoneal dialysis impact on quality of life in elderly].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Karan K ShahHealth Economics, The University of Sydney, NHMRC Clinical Trials Centre, Sydney, New South Wales, Australia.ORCID 0000-0002-9838-0894
Fliss E M MurtaghWolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.
Kevin McGeechanBiostatistics, School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.
Su CrailCentral Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Aine BurnsNephrology, Royal Free Hospital, London, UK.
Anh D TranHealth Economics, The University of Sydney, NHMRC Clinical Trials Centre, Sydney, New South Wales, Australia.
Rachael L MortonHealth Economics, The University of Sydney, NHMRC Clinical Trials Centre, Sydney, New South Wales, Australia.
The University of Sydney · AURoyal Adelaide Hospital · AUThe Royal Free Hospital · GBUniversity of Hull · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo measure health-related quality of life (HRQoL) and well-being in older people with end-stage kidney disease (ESKD) and to determine the association between treatment type and sociodemographic characteristics on these outcome measures. In addition, to assess the convergent validity between the HRQoL and well-being measure and their feasibility and acceptability in this population.

designProspective cross-sectional study.

settingThree renal units in the UK and Australia.

participants129 patients with ESKD managed with dialysis or with an estimated glomerular filtration ≤10 mL/min/1.73 m OUTCOME MEASURES: HRQoL and well-being were assessed using Short-Form six dimensions (SF-6D, 0-1 scale); Kidney Disease Quality of Life (KDQOL-36) (0-100 scale) and Investigating Choice Experiments Capability Measure-Older people (ICECAP-O, 0-1 scale). Linear regression assessed associations between treatment, HRQoL and well-being. Pearson's correlation coefficient assessed convergent validity between instruments.

resultsMedian age of 81 years (IQR 78-85), 65% males; 83 (64%) were managed with dialysis and 46 (36%) with conservative care. When adjusted for treatment type and sociodemographic variables, those managed on dialysis reported lower mean SF-6D utility (-0.05, 95% CI -0.12 to 0.01); lower KDQOL Physical Component Summary score (-3.17, 95% CI -7.61 to 1.27); lower Mental Component Summary score (-2.41, 95% CI -7.66 to 2.84); lower quality of life due to burden (-28.59, 95% CI -41.77 to -15.42); symptoms (-5.93, 95% CI -14.61 to 2.73) and effects of kidney disease (-16.49, 95% CI -25.98 to -6.99) and lower overall ICECAP-O well-being (-0.07, 95% CI -0.16 to 0.02) than those managed conservatively. Correlation between ICECAP-O well-being and SF-6D utility scores was strong overall, 0.65 (p<0.001), but weak to moderate at domain level.

conclusionsOlder people on dialysis report significantly higher burden and effects of kidney disease than those on conservative care. Lower HRQoL and well-being may be associated with dialysis treatment and should inform shared decision-making about treatment options. TRIAL REGISTRATION NUMBER: UK (IRAS project ID: 134360andREC reference 14/LO/0291) and Australia (R20140203 HREC/14/RAH/36).

Indexed as

Comprehensive Health CareKidney Failure, ChronicQuality of LifeAgedAged, 80 and overAustraliaCross-Sectional StudiesFemaleHumansMaleProspective StudiesRenal DialysisUnited Kingdomchronic renal failurechronic renal insufficiencydialysishealth economicspalliative carequality of life

Identifiers

PMID31110102
PMCPMC6530299
OpenAlexW2945521702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.