Evidence map›Paper›PMID 31110016›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Assembly of the complexes of oxidative phosphorylation triggers the remodeling of cardiolipin.

Yang Xu, Murari Anjaneyulu, Alec Donelian, Wenxi Yu, Miriam L Greenberg, Mindong Ren, Edward Owusu-Ansah, Michael Schlame

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 75 citations in OpenAlex.

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  18. A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. The critical role of cardiolipin in metazoan differentiation, development, and maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yang XuDepartment of Anesthesiology, New York University School of Medicine, New York, NY 10016.
Murari AnjaneyuluDepartment of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032.
Alec DonelianDepartment of Anesthesiology, New York University School of Medicine, New York, NY 10016.
Wenxi YuDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202.
Miriam L GreenbergDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202.
Mindong RenDepartment of Anesthesiology, New York University School of Medicine, New York, NY 10016.
Edward Owusu-AnsahDepartment of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032.
Michael SchlameDepartment of Anesthesiology, New York University School of Medicine, New York, NY 10016; michael.schlame@med.nyu.edu.
New York University · USColumbia University Irving Medical Center · USWayne State University · US

Funding

THE ROLE OF CARDIOLIPIN IN THE TCA CYCLE: IMPLICATIONS FOR BARTH SYNDROMER01HL117880 · NHLBI · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2014 to 2023
$3.0M
Aberrant Cardiolipin Dynamics in Barth Syndrome - Renewal - 1R01GM115593 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHLAME, MICHAEL · 2015 to 2023
$2.9M
Identifying Remote Regulators of Complex I Biogenesis in DrosophilaR35GM124717 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2017 to 2021
$2.2M
IGFBP-Mediated Local and Systemic Effects of Mitochondrial Dysfunction in Skeletal MusclesR21DK112074 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2016 to 2018
$594k
NHLBI NIH HHS R01 HL117880NIDDK NIH HHS R21 DK112074NIGMS NIH HHS R01 GM115593NIGMS NIH HHS R35 GM124717
6 · The paper itself

Abstract

Cardiolipin (CL) is a mitochondrial phospholipid with a very specific and functionally important fatty acid composition, generated by tafazzin. However, in vitro tafazzin catalyzes a promiscuous acyl exchange that acquires specificity only in response to perturbations of the physical state of lipids. To identify the process that imposes acyl specificity onto CL remodeling in vivo, we analyzed a series of deletions and knockdowns in

Indexed as

AnimalsCardiolipinsDrosophila melanogasterLipid BilayersMitochondriaMitochondrial MembranesMusclesOxidative PhosphorylationPhospholipidsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCardiolipinsLipid BilayersPhospholipidsSaccharomyces cerevisiae Proteinscardiolipinlipidsmembranemitochondriarespiration

Identifiers

PMID31110016
PMCPMC6561273
OpenAlexW2946573657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.