Evidence map›Paper›PMID 31109947›Full record

ArticleInfection and immunity2019

CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii.

Jose-Andres C Portillo, Jennifer Van Grol, Saad Saffo, Yalitza Lopez Corcino, Myriam Rodriguez, Barbara A Fox, David J Bzik, Nicole L Ward, George R Dubyak, Roxana E Rojas and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  6. A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jose-Andres C PortilloDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Jennifer Van GrolDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Saad SaffoDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Yalitza Lopez CorcinoDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Myriam RodriguezDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Barbara A FoxDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
David J BzikDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Nicole L WardDepartment of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
George R DubyakDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Roxana E RojasDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Zahra ToosiDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Carlos S SubausteDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA carlos.subauste@case.edu.
Case Western Reserve University · USUniversity School · USDartmouth College · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Systems Biology CoreP50AR055508 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI DIAZ-INSUA, MIREYA · 2007 to 2011
$6.8M
Psoriasis Center of Research TranslationP50AR070590 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 2017 to 2021
$6.5M
VISUAL SCIENCES TRAINING PROGRAMT32EY007157 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Johannes Friedrich von Lintig · 2000 to 2026
$5.5M
Autophagy and Ocular ToxoplasmosisR01EY018341 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2009 to 2024
$5.0M
Regulation of retinopathiesR01EY019250 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2010 to 2022
$3.7M
Kallikrein-PAR interactions in skin inflammationR01AR073196 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WARD, NICOLE LEANNE · 2018 to 2023
$3.3M
IL-17C mediated mechanisms of inflammationR01AR062546 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2013 to 2017
$1.9M
Remote Inflammation and AtherothrombosisR01AR063437 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2012 to 2016
$1.7M
Role of TLR2 engagement on CD4+ T cells in immunity to M. tuberculosisR21AI099494 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROJAS, ROXANA E. · 2012 to 2013
$432k
Neurogenic inflammation and psoriasiform dermatitisR21AR063852 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2013 to 2014
$370k
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY018341NEI NIH HHS R01 EY019250NEI NIH HHS T32 EY007157NIAID NIH HHS R21 AI099494NIAMS NIH HHS P50 AR055508NIAMS NIH HHS P50 AR070590NIAMS NIH HHS R01 AR062546NIAMS NIH HHS R01 AR063437NIAMS NIH HHS R01 AR073196NIAMS NIH HHS R21 AR063852
6 · The paper itself

Abstract

Little is known about whether pathogen invasion of neural tissue is affected by immune-based mechanisms in endothelial cells. We examined the effects of endothelial cell CD40 on

Indexed as

AnimalsAutophagyBrainCD40 AntigensCell MovementEndothelial CellsHSP70 Heat-Shock ProteinsLeukocytesMiceMice, Inbred C57BLRetinaToxoplasmaCD40 AntigensHSP70 Heat-Shock ProteinsautophagyCD40dendritic cellsendothelial cellsmonocytes

Identifiers

PMID31109947
PMCPMC6652775
OpenAlexW2946778369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.