Evidence map›Paper›PMID 31109946›Full record

ArticleInfection and immunity2019

A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas.

Carine Ysebaert, Philippe Denoël, Vincent Weynants, Lauren O Bakaletz, Laura A Novotny, Fabrice Godfroid, Philippe Hermand

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Differences in Pneumococcal andFrontiers in immunology · 2021
    Trial
  3. Article
  4. Exploiting haem-iron dependence of nontypeableFrontiers in cellular and infection microbiology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. NontypeableBiofilm · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Carine YsebaertGSK, Rixensart, Belgium.
Philippe DenoëlGSK, Rixensart, Belgium.
Vincent WeynantsGSK, Rixensart, Belgium.
Lauren O BakaletzDepartment of Pediatrics, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Laura A NovotnyDepartment of Pediatrics, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Fabrice GodfroidGSK, Rixensart, Belgium.
Philippe HermandGSK, Rixensart, Belgium philippe.hermand@gsk.com.
GlaxoSmithKline (Belgium) · BENationwide Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable

Indexed as

AnimalsBacterial AdhesionBacterial ProteinsBiofilmsChinchillaFemaleFimbriae ProteinsHaemophilus influenzaeHaemophilus VaccinesImmunizationMiceMice, Inbred BALB CNasopharynxOtitis MediaVaccines, SyntheticVitronectinBacterial ProteinsFimbriae ProteinsHaemophilus VaccinesVaccines, SyntheticVitronectinchinchillaHaemophilus influenzaemousePilAprotein Evaccines

Identifiers

PMID31109946
PMCPMC6652774
OpenAlexW2945676753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.