Evidence map›Paper›PMID 31109842›Full record

ReviewUltrasound in medicine & biology2019

Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.

Joseph Blackmore, Shamit Shrivastava, Jerome Sallet, Chris R Butler, Robin O Cleveland

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 246 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 4 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07518927 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Mapping Low-Intensity Focused Ultrasound (LIFU)-Evoked Brain Network Responses Using Intracranial Electrophysiological Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2031Enrolled30ConditionsLow Intensity Focussed Ultrasound, Electrodes, ImplantedArmsLow Intensity Focused Ultrasound
NCT07728994 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Safety and Feasibility Study of ATTN201 Repeated Subthalamic Nucleus Focused Ultrasound Stimulation for the Treatment of Obsessive Compulsive Disorder

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2028Enrolled40ConditionsObsessive Compulsive DisorderArmsLow Intensity Focused Ultrasound, Sham (No Treatment)
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 4 syntheses or guidelines pooled it, 523 citations in OpenAlex.

  1. Pooled it
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  10. Impact of Therapeutic Ultrasound on Metabolic Hormone Release From Thyroid Gland.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joseph BlackmoreInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Roosevelt Drive, Oxford, UK.
Shamit ShrivastavaInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Roosevelt Drive, Oxford, UK.
Jerome SalletWellcome Centre for Integrative Nueroimaging, Department of Experimental Psychology, University of Oxford, Oxford, UK.
Chris R ButlerNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Robin O ClevelandInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Roosevelt Drive, Oxford, UK. Electronic address: robin.cleveland@eng.ox.ac.uk.
University of Oxford · GBJohn Radcliffe Hospital · GB

Funding

Medical Research Council MR/K010395/1Wellcome TrustWellcome Trust 105651/Z/14/Z
6 · The paper itself

Abstract

Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US) is delivered to nervous system tissue, resulting in transient modulation of neural activity. This review summarizes the findings in the central and peripheral nervous systems from mechanistic studies in cell culture to cognitive behavioral studies in humans. The mechanisms by which US mechanically interacts with neurons and could affect firing are presented. An in-depth safety assessment of current studies shows that parameters for the human studies fall within the safety envelope for US imaging. Challenges associated with accurately targeting US and monitoring the response are described. In conclusion, the literature supports the use of US as a safe, non-invasive brain stimulation modality with improved spatial localization and depth targeting compared with alternative methods. US neurostimulation has the potential to be used both as a scientific instrument to investigate brain function and as a therapeutic modality to modulate brain activity.

Indexed as

BrainBrain DiseasesHumansNeuronsUltrasonic TherapyBrain stimulationMechanismsNeuromodulationNon-invasiveSafetyUltrasound

Identifiers

PMID31109842
PMCPMC6996285
OpenAlexW2944853512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.