Evidence map›Paper›PMID 31109646›Full record

ArticleBiochemical and biophysical research communications2019

Oxidative stress induces senescence in breast cancer stem cells.

Guangxian Zhong, Shenghui Qin, Danyelle Townsend, Bradley A Schulte, Kenneth D Tew, Gavin Y Wang

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
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  15. CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?International journal of molecular sciences · 2023
    Review
  16. Cancer stem cell fate determination: mito-nuclear communication.Cell communication and signaling : CCS · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Selenylated Imidazo[1,2Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Guangxian ZhongDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA; Department of Orthopaedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350000, PR China.
Shenghui QinDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Danyelle TownsendDepartment of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.
Bradley A SchulteDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Kenneth D TewDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC, 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.
Gavin Y WangDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA. Electronic address: wangy@musc.edu.
Medical University of South Carolina · USMUSC Hollings Cancer Center · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
Targeting the ROS-p38 MAPK Pathway as a Novel Strategy for Stem Cell ExpansionR21HL106451 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WANG, GAVIN YONG · 2011 to 2012
$404k
NCATS NIH HHS UL1 TR001450NHLBI NIH HHS R21 HL106451NIGMS NIH HHS P20 GM103542
6 · The paper itself

Abstract

Cancer stem cells (CSCs) have been shown to be resistant to current anticancer therapies and the induction of oxidative stress is an important mechanism of action for many anticancer agents. However, it is still largely unknown how CSCs respond to hydrogen peroxide (H

Indexed as

Cellular SenescenceApoptosisBreast NeoplasmsCell Line, TumorHumansHydrogen PeroxideMCF-7 CellsNeoplastic Stem CellsOxidative StressReactive Oxygen SpeciesHydrogen PeroxideReactive Oxygen SpeciesBreast cancerCancer stem cellsHydrogen peroxideOxidative stressSenescence

Identifiers

PMID31109646
PMCPMC6556123
OpenAlexW2945603611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.